Effective dosage of Oryzanol?

Clinical trials conducted in Japan have shown that 300 mg per day is the effective dose of Oryzanol.

Clinical Trials to study the Pharmacological effects of ‘ORYZANOL’

Study Component Daily Dose Study Design(Study Duration) Number of Subjects Pharmacological effect Ref.
Oryzanol 300 mg RCT*(8 weeks) 40 Post- menopausal women TC, LDL-C, TG, Lipid peroxides, HDL-C Ishihara M, Ito , Nakakita T, Maehama T, Hieda S, Yamamoto K and Ueno N
Nippon SankaFujinkaGokkaiZasshi, 34 (1982) 243-251
  300 mg RCT*(8 weeks) 80 Post- menopausal women TC, LDL-C, TG, Lipid peroxides, HDL-C Ishihara, 1984 Asia Oceania J ObstetGynecol 1984;10:317
  300 mg RCT*(13 weeks) 80 Hyper- cholesterolemics TC, LDL-C, TG, Yoshino G, Kazumi T, Amano M, Tateiwa M, Yamasaki T, Takashima S, Iwai M, Hatanaka H & Baba S, CurrTher Res, 45 (1989) 975
  300 mg RCT*(8 weeks) 20 Hyper- cholesterolemics TC, LDL-C, TG, Apolipoprotein B, Sasaki J, Takada Y &Handa K 1990
ClinTherap, 12 (1990) 263-268
  300 mg RCT*(8 weeks) 8 Hypothyroid Patients TSH Shimomura Y, Kobayashi I, Maruto S, Ohshima K, Mori M, Kamio N, Fukuda Endocrinologia Japonica [1980, 27(1):83-86]

TC - Total Cholesterol
LDL - Low Density lipoprotein
TG – Triglycerides
HDL- High Density Lipoprotein
TSH- Thyroid Stimulating Hormone