Is it Safe?

A long history of rice consumption by man and animals would suggest that gamma oryzanol does not cause much, if any toxicity. Still, Japanese companies have conducted safety tests on gamma oryzanol to satisfy Japanese government regulations regarding food additives and supplements. These tests began with determining if gamma oryzanol is toxic to animals by injecting ever increasing doses to arrive at the LD50 (lethal dose for 50% of the test animals). Such tests have revealed an acute LD50 of greater than 30gm/kg for mice, which would be equivalent to an average adult being injected with over 2100 grams (about 4 pounds) and surviving, meaning gamma oryzanol is extremely NON-
TOXIC!4 Furthermore, feeding large daily doses to baby mice and chicks led to no harmful effects and even caused an increase in body weight over controls. Thus Safe!