Health Benefits of Oryzanol


Health benefits of Oryzanol are proven worldwide. Lot of research has gone into this
subject so all its health benefits are mostly well established and well documented.
Some of its health benefits are enlisted below with some reference material.


 

1. Helps in Lowering cholesterol

a.) A scientific study conducted by Tufts University, Boston and University of Massachusetts Lowell, USA has revealed that oryzanol significantly helps in lowering down bad cholesterol and increasing good cholesterol at the same time.

- Source:- Lipids, Vol. 32, no. 3, (1997) 303-309, USA

b.) Human clinical studies conducted in the University of Lowell found that Rice Bran oil has significantly better cholesterol lowering properties than popular Olive Oil. Scientists have attributed this to presence of Oryzanol in the oil.

Source:- Arterioscler Thromb Vasc Biol. (Journal of American Heart Association)1994;14:549-556, Artherosclerosis, volume 88, Issues 2-3, June 1991, pages 133-142

c.) A Scientific Study conducted by scientists of Tufts university and University of Lowell on cholesterol lowering properties of Physically Refined Rice Bran oil relative to COCO and CANOLA, found out Physically refined Rice Bran Oil (Richest source of Oryzanol) to be the best among the three in cholesterol lowering. It also reduced Early atherosclerosis (fatty streak formation) significantly.

- Source:- Journal of Nutritional Biochemistry , USA16 (2005) 521-529)

d.) In a study conducted by National Institute of Nutrition, Indian Council of Medical Research, Rice bran oil showed greater reduction in bad cholesterols in comparison to Groundnut oil which has similar fatty acid profile. Scientists has attributed this to Oryzanol.

- Source-Journal of the American College of Nutrition, Vol. 10, No.4- (1991)

e.) In a Human Clinical study by Division of Nutrition AIIMS, India RBO (containing Oryzanol) was found to have significantly reduced bad cholesterol in comparison to Sunflower oil a PUFA rich oil. Other PUFA rich oils are Safflower, Soyabean and Corn.

- Source:- National Medical Journal of India 2005, 18: 292- 6

f.) A human clinical study was conducted by scientists of National Institute of Nutrition, Indian Council of Medical Research to prove hypolipidemic effect of RBO. They studied this on 12 hyperlipidemic patients, Subjects were told to replace their usual oil (any oil used previously) with Rice Bran oil. A significant ecrease in bad cholesterol was noticed after period of 15 days in all 12.

- Source:- National Medical Journal of India 2005, 18: 292- 6

g.) National Institute of Nutrition (The Apex body of Nutrition in India) in its Dietary guidelines for year 2011 has mentioned that Oryzanol found in Rice Bran Oil is helpful in reducing cholesterol and oxidative damage due to ageing, inflammation which occur in chronic diseases.

Source:- Dietary Guidelines for Indians – A Manual by National Institute of Nutrition, 2011 page no. 61


2. Effect On Hypertension

a. A Human Clinical Study by Indian Council of Medical Research has found the blend of Rice bran oil and Sesame oil in the ratio 80:20 to be really effective in reducing Hypertension and when this blend was coupled with popular medicine for Hypertension nifedipine, it showed even better results.The researchers believe this effect is mainly due to antioxidants present in the blend-- sesamin, sesamol and sesamolin in sesame oil, and oryzanol in rice bran oil.

- Source:- A Hindustan Times Newspaper report published on 23 September, 2012


 

3. Anti-Diabetic effect

a. A study conducted by Kainan University, Taiwan found out that Rice Bran Oil enriched with oryzanol Increases LDL-Receptor and HMG-CoA Reductase mRNA Expressions and Insulin Sensitivity in Rats with Streptozotocin/Nicotinamide-Induced Type 2 Diabetes


- Source:- Journal of Clinical Biochemistery and Nutrition, Japan., 45, 29–36, July 2009

b. In a study conducted by Nirma University India Oryzanol has been found to have protective effect on hyperglycemia- induced thermal hyperalgesia and oxidative stress which might be responsible for diabetes induced nerve damage or the disease called Diabetes Neuropathy.


- Source:-Brazilian Journal of Pharmacognosy [online]. 2012, 1092-1103. Epub Sep 06, 2012 .

c. A Study conducted by Kyungpook National University, Republic of Korea illustrated protective effect of Oryzanol and ferulic acid on high fat diet induced hyperglycemia via regulation of insulin Secretion and hepatic glucose regulating enzyme activities.

- Source:-Journal of Food Science, Korea Volume 76, Issue 1, pages H7–H10, January/February 2011


 

4. Protective Effect on Liver

a. Studies conducted by Nagasaki university, Japan suggests that y-Oryzanol is very effective against liver cirrhosis, cirrhosis is scarring of the liver and poor liver function. It is the final phase of chronic liver disease. Studies have attributed this to the effective antioxidant property of Oryzanol.


- Source:- Journal of Clinical Biochemistery and Nutrition, Japan., 12, 193-199, 1992

b. A Study by Tokyo university, Japan revealed that Oryzanol has a protective effect against alcohol-induced liver damage. It inhibited the oxidative stress which is a prime reason for liver damage.

- Source:- C. Chotimarkorn, H. Ushio / Phytomedicine 15 (2008) 951–958

 


5. Anti – carcinogenic effect

a. A Scientific study conducted by Ajou University Suwon, Republic of Korea has found Oryzanol to inhibit tumor growth in tumor bearing Mice.

- Source:- Journal of Molecular Nutrition and Food Research 2012 Jun;56(6):935-44

b. Department of Clinical Sciences, Colorado University has suggested the use of Rice Bran Bio Active components in prevention of several types of cancers, such as breast, liver, lungs and colorectal cancer. Rice bran bioactive components protect against tissue damage through the scavenging of free radicals and the blocking of chronic inflammatory responses.

- Source:- Journal of Advances in Nutrition, USA 2012 Sep 1;3(5):643-53

c. An End Point Tumor Study(EPT) on effect of Dietary fats on colon cancer in Fisher 344 male rats was
studied by Alabama A and M University, U.S.A on Soya, corn and Rice Bran Oil . Results of the study
found out inhibition of tumor growth only by rats fed on Rice Bran Oil.
- Source:-International Journal of Cancer Research 5 (1), 25-35, 2009


 

6. Effective in treatment of Gastrointestinal disorders including stress induced gastric and duodenal ulcers

a. A Study in Japan found out that an 8-day treatment with gamma-oryzanol, showed a significant inhibition of fasting ulcer and a 10-day treatment with the same dose of gamma-oyzanol in acetic acid ulcers lowered the serum level of gastrin.

- Source:- Journal of Folia Pharmacologica Japonica 1976 Nov;72(8):1001-11

b. Another Study in Japan reported that the oryzanol is effective against the stress induced ulcers.

- Source:- Journal of Folia Pharmacologica Japonica 1976 May;72(4):475-81

c. Another Study in Japan indicate that gamma-oryzanol has an antiulcerative action on gastric lesions

induced by CES and REM sleep deprivation, and it has a suppressive action on the facilitation of intestinal propulsion induced by Conditioned Emotional Stimuli.

- Source:- Journal of Folia Pharmacologica Japonica 1984 Dec;84(6):537-42


 

7. Anti-Inflammatory effect

a. A Study by Department of Food Science and Technology, Tokyo found out that Treatment with Oryzanol during the entire time course of treatment of colitis (swelling of the Intestine), suppressed the pathological conditions, including body weight loss, intestinal bleeding and diarrhoea, resulting in significant amelioration of intestinal inflammation .

- Source:-British Journal of Pharmacology (2008) 154, 812–824

b. A study conducted by Department of Pharmaceutical Sciences, Thailand yet again confirmed the anti inflammatory properties of Oryzanol.

- Source:- Journal of Medicinal Plants Research Vol. 6(6), pp. 1070-1077, 16 February, 2012


8. Osteoporosis

a. A study conducted on Ovariectomized rats (who typically lose substantial bone mineral density after the ovariectomy) were used as a model for postmenopausal osteoporosis. It was found that the addition of a 7% oryzanol rice bran oil (RBO) concentrate to the diets of ovariectomized rats resulted in less bone loss at several bone sites than control rats.

- A Thesis Submitted to the Graduate Faculty of the Louisiana State University and Agricultural and Mechanical College


 

9. Helpful in treating disorders of Menopause

a.At menopause the pituitary gland secretes excess amount of Follicle Stimulating Hormone and leutinizing Hormone (FSH & LH). A study in Japan has reported that Supplementation with Oryzanol reduces the over- secretion of these hormones.

- Source:- A Japanese Journal Nippon Naibunpi Gakkai zasshi 1980 Aug 20;56(8):1130-9

b.Clinical trials involving menopausal women and women who had their ovaries surgically removed, have revealed that 67-85 percent of women treated with gamma-oryzanol have experienced a significant reduction in menopausal symptoms.

- A Research article taken from http://www.meschinohealth.com/ArticleDirectory/Gamma-Oryzanol_Menopause_Treatment

c Another Study in Japan confirmed the efficacy and utility of gamma-Oryzanol on many complaints in climacteric disturbance and also on lipid metabolism.

- Source:- A Japanese Journal Nippon Naibunpi Gakkai zasshi 1982 Feb;34(2):243-51.


 

10.Skin

Oryzanol has been found to have many skin related benefits. The use of Oryzanol in sunscreen products, hair conditioners and moisturizing creams is on the increase in the United States

a. A study in Chiang Mai University,Thailand has found Oryzanol as a potential cosmetic raw- material. According to the study oryzanol helps in skin whitening, skin hydration and is anti ageing. Oryzanol may help to maintain skin function by improvement of skin microcirculation, protection against lipid peroxidation and direct stimulation of sebaceous gland function

- Source:- Journal of Pharmaceutical Biology, Thailand 2012 Feb;50(2):208-24

b.A Study by Natural Product Research and Development Center , Chiang Mai University Thailand has again confirmed skin hydration effect of oryzanol.

- Source:- Journal of Nanoscience and Nanotechnology ,Thailand Mar;11(3):2269-77

c. Oryzanol due to its antioxidant property is an effective Sunscreen and thus protects the skin from U-V Rays.


11. Effect on damage caused by Smoking

Nicotine is one of the major hazardous compounds of cigarette smoke and thus mimics most of the deleterious effects of cigarette smoking. It increases lipid peroxidation and thus causes oxidative cellular injury, which is believed to play a major role in the pathogenesis of several smoking-related diseases .

a. A study conducted by Department of biochemistery, Annamalai University India has found out that administration of Ferulic acid (Oryzanol is a Ferulic Acid Ester) reversed the damage induced by nicotine and increases the endogenous antioxidant defense system and protects the cells from oxidative damage, it quenches the free radicals, prevents them from attacking the membrane.

- Source:- Jounal of Toxicology, Machanisms and Methods 2005;15(6):375-81


 

12. Effect on Thyroid

a. A study conducted in Japan has found a single oral dose (300 mg) of gamma-oryzanol extracted from rice- bran oil to be effective, in significantly reducing elevated serum TSH levels in hypothyroid patients.

- Source:-Journal of Endocrinologia Japonica, Japan 1980 Feb 27(1): 83-86

b. In yet another study oryzanol reduced LH Hormone secreted by the Pituitary gland

- Source:- A Japanese Journal Nippon Naibunpi Gakkai zasshi 1980 Aug 20;56(8):1130-9.


 

13. Anti Oxidant Effects

Free radicals are the natural by-products of many oxidative metabolic processes within cells.These free radicals can cause damage to cell walls, certain cell structures and genetic material within the cells. Oryzanol found in rice
bran oil is also a potent antioxidant.One test-tube study found that oryzanol was more than four times as effective at stopping tissue oxidation as vitamin E.

1. In a Scientific study by university of Sassari, Italy, oryzanol improved the oxidative stability of oils which were very prone to lipoperoxidation because of their high content of polyunsaturated fatty acids.


- Source:- International Journal of pharmaceutics 2005 Aug 11;299(1-2):146-54

2. In a study by department of Food Science and Technolgy, Seoul National university of Technology when oryzanol was added to lard (Pig Fat) it remained stable on heating.


- Source:- Japanese Journal of Agricultural and Food Chemistery 2005 Dec 14;53(25):9747-50

3. In a study by Fisheries Laboratory, Kinki university Japan it was found that when Oryzanol added to brown fish meal diet not only suppressed the dark color pigmentation but also oxidative stress in cultured red sea
bream.


- Source:-Japanese Journal of Oleao Science 57, (2) 133-137 (2008)


14. Neuro Protective effect

Several studies have shown gamma oryzanol to be as effective as many drugs in reducing objective, systemic effects of stress. Normalization (ratherthansuppression) of the autonomicnervous system is the proposed mechanism of action of gamma oryzanol in reducing stress.

1. A joint Study by university of Kentucky,USA and university of Catania Italy has revealed that Oryzanol( which is a Ferulic Acid Ethyl Ester) has therapeutic ability to protect body from oxidative stress-related neurodegenerative disorders like Alzheimer.

- Source:- Journal of Neurochemistry International 48 (2006) 318–327


 

15. A Natural Steroid, testosterone Booster, helps in building lean muscles

An unpublished study by Bucci, L., Stiles, J., Sparks, W., and DeLuca,D.,1987, compared anabolic steroid users to those athletes supplemented with gamma oryzanol. Initially, the anabolic steroid users showed greater gains in girth measurements, but by 16 weeks, the gamma oryzanol users exhibited greater girth measurement increases that all steroid users, without ANY side effects! And the dose for gamma oryzanol is low.


The antioxidant property of Oryzanol is believed to be responsible for this favourable effect. Very preliminary evidence suggests that γ- oryzanol may increase endorphin release (a feel good hormone) and aid muscle development.

These findings have created an interest in using γ-oryzanol as a sports supplement, companies in U.S are selling Oryzanol based Health Supplements for Body building.

http://www.gammalabs.net/ visit to check company products.


 

16. Effect on Nephrotic Syndrome

Nephrotic syndrome is a nonspecific disorder in which the kidneys are damaged, causing them to leak large amounts of protein from the blood into the urine. Hyperlipidemia has been recognised since long as a common finding in patients of nephrotic syndrome. Serum Cholesterol and its fractions, high density lipoproteins (HDL), Low dendsity Lipoproteins( LDL), very low density lipoproteins (VLDL) and HDL/LDL ratio are significantly altered in patiets of nephrotic Syndrome.

A Study by Aligarh Muslim University, India has revealed that Rice Bran oil (Rich in Oryzanol) due to its hyperlipidemic property has been found to be beneficial for patients of Nephrotic Syndrome..

- Source:- Indian Journal of Nephrology 2005;15: 10-13