Studies Conducted On
Anti-anxiety/stress and neuroprotective properties of Gamma-Oryzanol
Year Of Study: 2021
Title Of The Study: The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson’s Disease in Rats
The findings of this study suggest that the nutraceutical rice bran that contains γ- oryzanol, Vitamin-E, ferulic acid etc., may underlie the adjuvant susceptibility towards rotenone-induced Parkinson disease in experimental rats.
Year Of Study: 2021
Title Of The Study: γ-Oryzanol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in Drosophila melanogaster
This clinical trials presents that Gamma oryzanol is a potential antidepressant compound.
Year Of Study: 2021
Title Of The Study: Protective effect of gamma-oryzanol against manganese-induced toxicity in Drosophila melanogaster
As per this study, Gamma Oryzanol effectively attenuates detrimental changes associated with Mn exposure in Drosophila melanogaster, reinforcing its neuroprotective action/potential.
Year Of Study: 2020
Title Of The Study: ORY supplementation mitigates acetaminophen-induced acute liver failure in male mice: role of oxidative stress and apoptotic markers
The study suggests about the protective effect of gamma oryzanol (ORY) supplementation was due to modulation of antioxidant defenses avoiding the apoptotic process.
Year Of Study: 2020
Title Of The Study: Gamma Oryzanol Alleviates High-Fat Diet-Induced Anxiety-Like Behaviors Through Downregulation Of Dopamine And Inflammation In The Amygdala Of Mice / Salina Akter, Kazi Rasel Uddin, Hiroyuki Sasaki, Shigenobu Shibata / Frontiers In Pharmacology
In this study, Gamma Oryzanol potentially blocked high-fat diet (HFD)- induced anxiety-like behaviours via significant improvement of the primary behavioural parameters in behavioural tests. Findings of this study strongly suggest that Gamma Oryzanol exerts anxiolytic-like effects, possibly through down regulation of dopamine and via expression of pro-inflammatory cytokines TNF-α and IL-1β in the case of chronic HFD exposure.
Year Of Study: 2018
Title Of The Study: Gamma-Oryzanol Ameliorates The Acute Stress-Induced By Behavioral Anxiety Testing In Mice / Salina Akter, Hiroyuki Sasaki, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata / Journal Of Pharmacological Sciences
From the findings of this study, it was concluded that Gamma Oryzanol might act as a potential complementary or alternative anxiolytic drug in the treatment of unavoidable weak-stress-induced anxiety.
Year Of Study: 2018
Title Of The Study: Gamma-Oryzanol For Behavioural And Psychological Symptoms Of Dementia / Masahiko Fujii, James P Butler, Hidetada Sasaki / Japanese Psychogeriatric Society
In this study, significant improvements in agitation/aggression, anxiety, irritability/lability, and aberrant motor activity were observed in Patients with Alzheimer’s disease, vascular dementia, or dementia with Lewy bodies after they used Gamma Oryzanol for four weeks. From the findings of this study, it was concluded that Gamma Oryzanol can significantly improve the symptoms of dementia, without compromising cognitive function or causing other side effects.
Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/psyg.12303
Year Of Study: 2015
Title Of The Study: Effectiveness of γ-oryzanol in reducing neuromotor deficits, dopamine depletion and oxidative stress in a Drosophila melanogaster model of Parkinson’s disease induced by rotenone
This study suggests about neuroprotective potential of gamma oryzanol (ORY) and that this effect can be potentially due to its antioxidant action. In conclusion, the present results show that ORY is effective in reducing the ROT induced toxicity in D. melanogaster, which showed a neuroprotective action, possibly due to the presence of the antioxidant constituents such as the ferulic acid.
Year Of Study: 2015
Title Of The Study: Rice Bran Extract Improves Mitochondrial Dysfunction In Brains Of Aged NMRI Mice / Stephanie Hagl, Dirk Berressem, Rehka Grewal, Nadine Sus, Jan Frank, Gunter P Eckert / Nutritional Neuroscience
From the results of this study, it was concluded that Gamma Oryzanol is a promising candidate nutraceutical for the prevention of age-related neurodegenerative diseases.
Year Of Study: 2014
Title Of The Study: Mechanistic Basis For Protection Of Differentiated SH-SY5Y Cells By Oryzanol-Rich Fraction Against Hydrogen Peroxide-Induced Neurotoxicity / Norsharina Ismail, Maznah Ismail, Mustapha Umar Imam, Nur Hanisah Azmi, Siti Farhana Fathy, Jhi Biau Foo And Muhammad Firdaus Abu Bakar / BMC Complementary And Alternative Medicine
This study investigated the neuroprotective properties of Gamma Oryzanol against hydrogen peroxide-induced neurotoxicity in differentiated human neuroblastoma SH-SY5Y cells. The findings of this study suggest that Gamma Oryzanol may be an effective anti-oxidant that could prevent oxidative stress-induced neurodegenerative disorders.
