Gamma Oryzanol

Studies Conducted On

Anti-anxiety/stress and neuroprotective properties of Gamma-Oryzanol

Year Of Study: 2020

Title Of The Study: Gamma Oryzanol Alleviates High-Fat Diet-Induced Anxiety-Like Behaviors Through Downregulation Of Dopamine And Inflammation In The Amygdala Of Mice / Salina Akter, Kazi Rasel Uddin, Hiroyuki Sasaki, Shigenobu Shibata / Frontiers In Pharmacology

In this study, Gamma Oryzanol potentially blocked high-fat diet (HFD)- induced anxiety-like behaviours via significant improvement of the primary behavioural parameters in behavioural tests. Findings of this study strongly suggest that Gamma Oryzanol exerts anxiolytic-like effects, possibly through down regulation of dopamine and via expression of pro-inflammatory cytokines TNF-α and IL-1β in the case of chronic HFD exposure.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090127/

Year Of Study: 2018

Title Of The Study: Gamma-Oryzanol Ameliorates The Acute Stress-Induced By Behavioral Anxiety Testing In Mice / Salina Akter, Hiroyuki Sasaki, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata / Journal Of Pharmacological Sciences

From the findings of this study, it was concluded that Gamma Oryzanol might act as a potential complementary or alternative anxiolytic drug in the treatment of unavoidable weak-stress-induced anxiety.

Link: https://pubmed.ncbi.nlm.nih.gov/30322802/

Year Of Study: 2018

Title Of The Study: Gamma-Oryzanol For Behavioural And Psychological Symptoms Of Dementia / Masahiko Fujii, James P Butler, Hidetada Sasaki / Japanese Psychogeriatric Society

In this study, significant improvements in agitation/aggression, anxiety, irritability/lability, and aberrant motor activity were observed in Patients with Alzheimer’s disease, vascular dementia, or dementia with Lewy bodies after they used Gamma Oryzanol for four weeks. From the findings of this study, it was concluded that Gamma Oryzanol can significantly improve the symptoms of dementia, without compromising cognitive function or causing other side effects.

Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/psyg.12303

Year Of Study: 2015

Title Of The Study: Rice Bran Extract Improves Mitochondrial Dysfunction In Brains Of Aged NMRI Mice / Stephanie Hagl, Dirk Berressem, Rehka Grewal, Nadine Sus, Jan Frank, Gunter P Eckert / Nutritional Neuroscience

From the results of this study, it was concluded that Gamma Oryzanol is a promising candidate nutraceutical for the prevention of age-related neurodegenerative diseases.

Link: https://pubmed.ncbi.nlm.nih.gov/26241203/

Year Of Study: 2014

Title Of The Study: Mechanistic Basis For Protection Of Differentiated SH-SY5Y Cells By Oryzanol-Rich Fraction Against Hydrogen Peroxide-Induced Neurotoxicity / Norsharina Ismail, Maznah Ismail, Mustapha Umar Imam, Nur Hanisah Azmi, Siti Farhana Fathy, Jhi Biau Foo And Muhammad Firdaus Abu Bakar / BMC Complementary And Alternative Medicine

This study investigated the neuroprotective properties of Gamma Oryzanol against hydrogen peroxide-induced neurotoxicity in differentiated human neuroblastoma SH-SY5Y cells. The findings of this study suggest that Gamma Oryzanol may be an effective anti-oxidant that could prevent oxidative stress-induced neurodegenerative disorders.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528700/