Studies Conducted On
Anti-gastric, anti-ulcer and liver-protecting properties of Gamma-Oryzanol
Year Of Study: 2021
Title Of The Study: Exploring The Interactions of a Natural Gamma-Oryzanol with Human Serum Albumin: Surface Plasmon Resonance, Fluorescence, and Molecular Modeling Studies
Based on the fluorescence data analysis, ORY can form a non-fluorescent complex with HSA and induce static quenching of the emission intensity of HSA. Also, the high value of K SV (34.69 × 104 M-1) confirmed a high sensitivity of HSA toward ORY. Helps in maintaining liver functioning enzymes and activity
Year Of Study: 2021
Title Of The Study: The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome
The results showed that ORY pre-treatment significantly reduced the levels of AST and ALT, relieved hepatocellular damage and apoptosis, and attenuated the exhaustion of SOD and GSH and accumulation of MDA and MPO. Interestingly, ORY treatment could significantly decreased ER stress. The potential effect of ORY in modulating oxidative stress, endoplasmic reticulum stress, and inflammasome activation during HIR
Year Of Study: 2019
Title Of The Study: Gamma-Oryzanol Prevents Ethanol-Induced Liver Injury By Ameliorating Oxidative Stress And Modulating Apoptosis-Related Protein Expression In Mice / Lijuan Zhu, Siting Xiang, Zhaoping Ou, Chaoyang Ma, Xianglian Yi, Lin Huang, Yurong Ma, Zengenni Liang, Zhihang Yuan, Lixin Wen, Rongfang Li, Jing Wu, Zhuliang Tan, JineYi / Journal Of Functional Foods
From the findings of this study, it was concluded that Gamma Oryzanol protects against liver injury induced by ethanol by improving the antioxidant defence system, ameliorating oxidative stress and regulating apoptosis-related protein expression. It was further suggested that as a feasible antioxidant, Gamma Oryzanol should be thought of as an upcoming functional ingredient for preventing alcoholic liver injury.
Link: https://www.sciencedirect.com/science/article/abs/pii/S1756464619304566
Year Of Study: 2018
Title Of The Study: Potential Gastroprotective Activity Of Rice Bran ( Oryza Sativa L.) Extracted By Ionic Liquid-Microwave-Assisted Extraction Against Ethanol-Induced Acute Gastric Ulcers In Rat Model / Elsa Trinovita, Fadlina Chany Saputri, Abdul Mun’im / Scientia Pharmaceutica
The results of this study showed that Gamma Oryzanol is effective as a gastroprotective therapy sourced from natural ingredients in treating the incidence of gastric acidity and gastric ulcers induced by Alchohol consumption.
Year of Study: 2015
Title Of the Study: Study on the efficacy of the combined regimen of nifedipine and oryzanol in the clinical treatment of children with functional abdominal pain Li Jinluan Taishan People’s Hospital, Guangdong Jiangmen 529200)
From the findings of this study, it was concluded that the combination of nifedipine and oryzanol tablet has a more significant clinical effect in the treatment of children with functional abdominal pain, and has a synergistic effect, which is worthy of promotion and application.
Year Of Study: 2008
Title Of The Study: The Effect Of Trans-Ferulic Acid And Gamma-Oryzanol On Ethanol-Induced Liver Injury In C57BL Mouse / Chatchawan Chotimarkorn, Hideki Ushio / Phytomedicine
The results of this study demonstrate that gamma-oryzanol exert a protective action on liver injury induced by chronic ethanol (alcohol) ingestion.
Year Of Study: 1992
Title Of The Study: Effect Of Γ-Oryzanol On Experimental Liver Cirrhosis In Spontaneously Hypertensive Rats (SHR) / Masahiro ITO, Chao-Tien HSU, Kazuko SHICHIJO, Ichiro SEKINE / Journal Of Clinical Biochemistry And Nutrition
Based upon the results of this study, it was suggested that Gamma Oryzanol is very effective against lipogenic liver cirrhosis
Link: https://www.jstage.jst.go.jp/article/jcbn1986/12/3/12_3_193/_article/-char/ja/
Year Of Study: 1984
Title Of The Study: Effects Of Gamma-Oryzanol On Gastric Lesions And Small Intestinal Propulsive Activity In Mice / Y Ichimaru, M Moriyama, M Ichimaru, Y Gomita / Folia Pharmacologica Japonica
The results of this study indicate that gamma-oryzanol has an antiulcerative action on gastric lesions induced by Conditional emotional stimuli (CES) and REM sleep deprivation, and it has a suppressive action on the facilitation of intestinal propulsion induced by CES.
Year Of Study: 1980
Title Of The Study: Effects Of Gamma-Oryzanol On The Movements Of Stomach And Ileum In The Dog / T Mizonishi, T Semba / Japanese Journal Of Smooth Muscle Research
The results of this study indicate that gamma-Oryzanol produces the enhancement as well as inhibition of gastric and ileal movements. These effects may be produced by the reaction to the central nervous system of the gastric and ileal movements.
Year Of Study: 1978
Title Of The Study: Effects Of Gamma-Oryzanol And Atropine On Gastric Secretion Stimulated By Insulin Or 2-Deoxy-D- Glucose / K Mizuta, K Itaya / Folia Pharmacologica Japonica
In this study pretreatment with gamma-oryzanol (100 mg/kg, s.c., once daily x 5) depressed the gastric secretion stimulated by insulin or 2-deoxy-D- glucose. From these results, it is considered that the inhibitory action of gamma-oryzanol on gastric secretion may be due to depression of the vagus system
Year Of Study: 1978
Title Of The Study: Effects Of Gamma-Oryzanol On Gastric Secretions In Rats / K Mizuta, H Kaneta, K Itaya / Folia Pharmacologica Japonica
The results of this study indicate that the gastric antisecretory effect of gamma-oryzanol is mediated by the vagus nerve which plays a role in the action of gastrin.
Year Of Study: 1977
Title Of The Study: Studies On Gamma-Oryzanol. III. Influence Of Gamma-Oryzanol On Circadian Rhythms Of Serum Gastrin, 11-OHCS And Gastric Secretion In Rats / K Itaya, J Kiyonaga, M Ishikawa, K Mizuta / Folia Pharmacologica Japonica
In this study pretreatment of rats with gamma- oryzanol 100 mg/kg, s.c., for 5 days tended to decrease serum gastrin levels and gastric secretion and to increase serum 11-OHCS. Suppressive patterns of serum gastrin and gastric secretion following the pretreatment with gamma-oryzanol corresponded to the circadian rhythms in the antiulcerogenic action of gamma-oryzanol.
Year Of Study: 1976
Title Of The Study: Studies Of Gamma-Oryzanol. (2) The Antiulcerogenic Action / K Itaya, J Kitonaga, M Ishikawa / Folia Pharmacologica Japonica
In this study an 8-day treatment with gamma-oryzanol, 100 mg/kg, s.c., showed significant inhibition of fasting ulcer, while the 5-day pretreatment exerted slight effects on ulcers by pylorus-ligation or stress-atropine. A 10-day treatment with the same dose of gamma-oryzanol in acetic acid ulcers lowered the serum level of gastrin. It is suggested that the monoaminergic neuron system is involved in the anti-ulcer action of gamma- oryzanol.
Year Of Study: 1976
Title Of The Study: Studies Of Gamma-Oryzanol (1). Effects On Stress- Induced Ulcer / K Itaya, J Kiyonaga / Folia Pharmacologica Japonica
The results of this study indicate that the antiulcerogenic action of gamma-oryzanol is due to the participation of the autonomic nervous system, but not the hypophyseoadrenal axis.
