Studies Conducted On
Anti-cancer properties of Gamma-Oryzanol
Year of Study: 2015
Title of the Study: Gamma-Oryzanol reduces caveolin-1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines /Gabriela E Hirsch, Mariana M Parisi, Leo A M Martins, Claudia M B Andrade, Florencia M Barbé- Tuana, Fátima T C R Guma / The Prostate
From the findings of this study it was concluded that Gamma Oryzanol shows a promising adjuvant role in treatment of prostate cancer.
Year of Study: 2013
Title of the Study: Antioxidant effects of gamma-oryzanol on human prostate cancer cells / Papavadee Klongpityapong, Roongtawan Supabphol, Athikom Supabphol / Asian Pacific Journal of Cancer Prevention
In this study, gamma-oryzanol, significantly inhibited cell growth in both prostate cancer cell lines, DU145 and PC3. This study highlighted effects of gamma-oryzanol via the down-regulation of antioxidant genes, catalase and GPX, not cytotoxic roles. This might be interesting for adjuvant chemotherapy to make prostate cancer cells more sensitive to free radicals. It might be useful for the reduction of cytotoxic agents and cancer chemoprevention.
Year of Study: 2012
Title of the Study: Dual inhibition of γ-oryzanol on cellular melanogenesis: inhibition of tyrosinase activity and reduction of melanogenic gene expression by a protein kinase A-dependent mechanism / Hee-jin Jun, Ji Hae Lee, Bo-Ram Cho, Woo-Duck Seo, Hang-Won Kang, Dong-Woo Kim, Kang- Jin Cho, Sung-Joon Lee / Journal of Natural Products
This study demonstrated the anticarcinogenic effects of Gamma Oryzanol. The results of this study suggest that Gamma Oryzanol has dual inhibitory activities for cellular melanogenesis by inhibiting tyrosinase enzyme activity and reducing microphthalmia-associated transcription factor and target genes in the protein kinase A.
Year of Study: 2012
Title of the Study: Dietary rice bran component γ-oryzanol inhibits tumor growth in tumor-bearing mice / Sung Phil Kim, Mi Young Kang, Seok Hyun Nam, Mendel Friedman / Molecular Nutrition and Food Research
This study concluded that induction of NK activity, activation of macrophages and inhibition of angiogenesis seem to contribute to the inhibitory mechanism of tumor regression by Gamma Oryzanol
Year of Study: 2009
Title of the Study: A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis / Carrie K L Kong, W S Lam, Lawrence C M Chiu, Vincent E C Ooi, Samuel S M Sun, Yum-Shing Wong / Biochemical Pharmacology
The findings of this study demonstrated that cycloartenyl ferulate, a major component of Gamma Oryzanol, showed prominent in vitro growth inhibition on human colorectal adenocarcinoma SW480. The anticancer activity of CF was further illustrated by its ability to induce significant regression of SW480 xenograft in nude mice.
Year of Study: 2003
Title of the Study: Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice / Sylvia S Ng, William D Figg / Anticancer research
The results of this study demonstrated that herbal supplements containing Gamma Oryzanol inhibit the growth of prostate tumour xenografts, possibly in part by antiangiogenic mechanisms.
Year of Study: 1998
Title of the Study: Inhibitory effect of cycloartenol ferulate, a component of rice bran, on tumor promotion in two-stage carcinogenesis in mouse skin / K Yasukawa, T Akihisa, Y Kimura, T Tamura, M Takido / Biological and Pharmaceutical Bulletin
In this study, the cycloartenol ferulate, the main ingredient of Gamma Oryzanol, markedly inhibited the tumour-promoting effect of O-tetradecanoylphorbol-13-acetate.