Gamma Oryzanol

Studies Conducted On

Anti-inflammatory properties of Gamma-Oryzanol

Year Of Study: 2019

Title Of The Study: Gamma-Oryzanol Prevents LPS-Induced Brain Inflammation And Cognitive Impairment In Adult Mice / Andrea Mastinu, Sara Anna Bonini, Wiramon Rungratanawanich, Francesca Aria, Mariagrazia Marziano, Giuseppina Maccarinelli, Giulia Abate, Marika Premoli, Maurizio Memo, And Daniela Uberti / Nutrients MDPI

The results of this study suggest that chronic consumption of γ-oryzanol can revert the LPS-induced cognitive and memory impairments by promoting hippocampal antioxidant and anti-inflammatory molecular responses.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520753/

Year Of Study: 2017

Title Of The Study: Anti-Inflammatory And Antioxidative Stress Effects Of Oryzanol In Glaucomatous Rabbits / Shital S. Panchal, Rajesh K. Patidar, Abhishek B. Jha, Ahmed A. Allam, Jamaan Ajarem And Shital B. Butani1 / Journal Of Ophthalmology

In this study, Oryzanol showed protective effect against glaucoma by its antioxidative stress and anti-inflammatory property. Treatment with oryzanol can reduce optic nerve damage.

Link: https://www.hindawi.com/journals/joph/2017/1468716/

Year Of Study: 2016

Title Of The Study: Dietary Gamma Oryzanol Plays A Significant Role In The Anti-Inflammatory Activity Of Rice Bran Oil By Decreasing Pro-Inflammatory Mediators Secreted By Peritoneal Macrophages Of Rats / Y Poorna Chandra Rao, D Sugasini, B R Lokesh / Biochemical And Biophysical Research Communications

The results of this study indicated that Gamma Oryzanol supplemented in dietary oils play a significant role in reducing the secretion of pro-inflammatory mediators by macrophages. Hence Gamma Oryzanol in RBO significantly contributed to the anti-inflammatory properties of RBO.

Link: https://pubmed.ncbi.nlm.nih.gov/27693794/

Year Of Study: 2015

Title Of The Study: Rice Bran Prevents High-Fat Diet-Induced Inflammation And Macrophage Content In Adipose Tissue / Maria Luisa Justo, Carmen Claro, Maximilian Zeyda, Thomas M Stulnig, María Dolores Herrera, Rosalía Rodríguez-Rodríguez / European Journal Of Nutrition

In this study, pro-inflammatory biomarkers in white adipose tissue (WAT) such as IL-6 and IL-1β were significantly decreased in high-fat-fed mice treated with rice bran enzymatic extract (RBEE) containing Gamma Oryzanol. From the findings of this study, it was concluded that RBEE containing Gamma Oryzanol may be considered an alternative nutritional complement over metabolic syndrome and its complications.

Link: https://pubmed.ncbi.nlm.nih.gov/26266932/

Year: 2013

Title Of the Study: Clinical study of oryzanol in the adjuvant treatment of preschool children with variant cough Liang Zhangcong, Lan Haiping, Zhuo Haiyan

(Henggang People’s Hospital, Longgang District, Shenzhen, Guangdong ,518115)

Findings: The use of oryzanol, a common and less side-effect drug, was used to assist in the treatment of variant cough and observe the effect. The results showed that the use of conventional drugs in the pre-school children with cough variant asthma was beneficial to the patients’ emotional stability, significantly reducing the anxiety and other adverse emotions of children, enhancing the effect of Budesonide aerosol on children, helping to control the cough of children, effectively improving clinical efficacy, and mild adverse reactions, In addition, the price of oryzanol is cheap and the curative effect is safe, which is suitable for clinical application.

Link: https://oryzanol.in/wp-content/uploads/2021/06/11_Clinical-study-of-oryzanol-in-adjuvant-treatment-.pdf

Year: 2011

Title Of the Study:  Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion

Reiko Nagasaka1, Tomoteru Yamsaki, Asako Uchida, Kazuyuki Ohara, Hideki Ushio,2 Department of Food Science & Technology, Tokyo University of Marine Science and Technology, 5-7 Konan 4, Minato, Tokyo 108-8477, Japan

Findings: The present study has successfully demonstrated that ORZ would recuperate the hypoadiponectine- mia induced by ingestion of beef tallow. Together with our previous examinations (Islam et al. 2008, 2009; Nagasaka et al. 2007; Ohara et al. 2009; Oka et al. 2010), diverse physiological functions of ORZ in crop bran might be promising us to prevent chronic inflammations in the pathogeneses of the metabolic or insulin resistance syndromes (Gurnell et al. 2003; Lopez-Candales 2001; Moller 2001; Wilson and Grundy 2003a,b).

LINK-: https://pubmed.ncbi.nlm.nih.gov/21310601/

Year Of Study: 2011

Title Of The Study: Antioxidant And Anti-Inflammatory Activities Of Gamma-Oryzanol Rich Extracts From Thai Purple Rice Bran / Chalermpong Saenjum, Chaiyavat Chaiyasut, Sunee Chansakaow, Maitree Suttajit And Busaban Sirithunyalug / Journal Of Medicinal Plants Research

The results of this study indicate that Gamma Oryzanol rich extracts from rice bran are acting as a lipophilic radical scavenger better than a hydrophilic radical scavenger. Moreover, these extracts exert a potent anti-inflammatory activity.

Link: https://www.researchgate.net/publication/271185161_Antioxidant_and_anti-inflammatory_activities_of_gamma-oryzanol_rich_extracts_from_Thai_purple_rice_bran


Year Of Study: 2009

Title Of The Study: Anti‐Inflammatory Effects Of Phytosteryl Ferulates In Colitis Induced By Dextran Sulphate Sodium In Mice / M S Islam T Murata M Fujisawa R Nagasaka H Ushio A M Bari M Hori H Ozaki / British Journal Of Pharmacology

From the findings of this study, it was concluded that phytosteryl ferulates (a component of Gamma Oryzanol) could be new potential therapeutic and/or preventive agents for gastrointestinal inflammatory diseases. Their anti‐inflammatory effect could be mediated by inhibition of NF‐κB activity, which was at least partly due to the antioxidant effect of the FA moiety in the structure of phytosteryl ferulates.

Link: https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1038/bjp.2008.137

Year Of Study: 2009

Title Of The Study: Antioxidant, Free Radical–Scavenging, And NF-ΚB–Inhibitory Activities Of Phytosteryl Ferulates: Structure-Activity Studies / Md. Shafiqul Islam, Hiroshi Yoshida, Naoaki Matsuki, Kenichiro Ono, Reiko Nagasaka, Hideki Ushio, Ying Guo, Toshiyuki Hiramatsu, Takamitsu Hosoya, Takahisa Murata, Masatoshi Hori, And Hiroshi Ozaki/ Journal Of Pharmacological Sciences.

This study revealed that phytosteryl ferulates present in Gamma Oryzanol are responsible for the antioxidant and anti-inflammatory activity via reactive oxygen species (ROS) scavenging and inhibition of ROS production.

Link: https://www.jstage.jst.go.jp/article/jphs/111/4/111_09146FP/_article

Year Of Study: 2003

Title Of The Study: Anti-Inflammatory Effects Of Γ-Oryzanol /S. Terada And K. Haruta / Journal Of Natural Medicines

In this study, γ-oryzanol inhibited the increase in swelling of the hind paw in a dose-dependent manner (1-100 mg/kg). These results suggested that γ-oryzanol had the therapeutic potential for inflammatory disease.

Link: https://www.researchgate.net/publication/286942681_Anti-inflammatory_effects_of_g-oryzanol