Gamma Oryzanol

Studies Conducted On

Effects of Gamma-Oryzanol in reducing Obesity

Year of Study: 2018

Title of the Study: Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-α Axis/ Artur Junio Togneri Ferron, Fabiana Kurokawa Hasimoto, Pedro Henrique Rizzi Alves, Jéssica Leite Garcia, Klinsmann Carolo dos Santos , Fernando Moreto, Vanessa dos Santos Silva , Ana Lúcia A. Ferreira, Igor Otávio Minatel, and Camila Renata Corrêa / Hindawi Oxidative Medicine and Cellular Longevity

The results of this study confirm that Gamma Oryzanol is able to modulate PPAR-α expression, inflammation and oxidative stress pathways improving obesity-induced renal disease.

Link: http://downloads.hindawi.com/journals/omcl/2018/1278392.pdf

Year of Study: 2017

Title of the Study: Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice / Chisayo Kozuka, Tadashi Kaname, Chigusa Shimizu-Okabe, Chitoshi Takayama, Masato Tsutsui, Masayuki Matsushita, Keiko Abe, Hiroaki Masuzaki / Diabetologia

This study demostrated that Gamma Oryzanol ameliorates high fat diet-induced DNA hypermethlation of the promoter region of dopaine D2 receptor in the striatum, a pivotal regulator of the brain reward system, resulting in hedonic overeating. This study highlights Gamma Oryzanol as a promising antiobesity substance with the distinct property of being a novel epigenetic modulator.

Link: https://pubmed.ncbi.nlm.nih.gov/28528402/

Year of Study: 2015

Title of the Study: Effects of ferulic acid and γ-oryzanol on high-fat and high-fructose diet-induced metabolic syndrome in rats / Ou Wang, Jia Liu, Qian Cheng, Xiaoxuan Guo, Yong Wang, Liang Zhao, Feng Zhou, Baoping Ji / Plos One

This study investigates the effects of Gamma Oryzanol on alleviating high-fat and high-fructose diet (HFFD) -induced metabolic syndrome parameters. From the findings of this study it was concluded that Gamma Oryzanol is effective in alleviating HFFD-induced obesity, hyperlipidemia, hyperglycemia, hepatic injury and insulin resistance. Thus Gamma Oryzanol could be used as a dietary supplement to alleviate the deleterious effects of HFFD.

Link: https://pubmed.ncbi.nlm.nih.gov/25646799/

Year of Study: 2008

Title of the Study: Supplementation of Conjugated Linoleic Acid with γ-Oryzanol for 12 Weeks Effectively Reduces Body Fat in Healthy Overweight Korean Women / Jung Hee Kim, Ok Hyun Kim, Yeong Lae Ha and Jeong Ok Kim / Journal of Food Science and Nutrition

The findings of this study suggest that Gamma Oryzanol could be a useful ingredient to mix with conjugated linolenic acid for the reduction of human body fat.

Link: https://www.koreascience.or.kr/article/JAKO200828955288431.do