Clinical Trials on
Gamma Oryzanol & formulations with Gamma Oryzanol as active ingredient on Gastro-intestinal issues
Title Of The Study: Oryzanol therapy for ulcerative colitis
Since the summer 1966, the author has had chances, through the courtesy of Nakataki Pharmaceutical Industry Co., Inc., of clinical applications of a medical product called y-Oryzanol (y-OZ) on four patients of ulcerative colitis. y-OZ, a derivative from Oryzanol which is a mixture of several types of ferulates of triterpenoid alcohols and small amount of other components extracted from rice bran and rice germ oil, is said to be effective to what is called autonomic nervous syndrome. The four patients, having had sanguinous purulent or mucous appearance in their feces, but shown no detectable infectious evidence and been considered, in every respect, to be of acute phase of ulcerative colitis, were originally treated with ordinary methods, that is, antibiotics, steroids, A luid infusions or vitamins, without any significant improvement. Then, they were given y-OZ preparations, daily 10mg intra muscularly and/or 3 tablets (one tablet contains 3 mg of y-0Z) orally. The results were remarkable. They appeared to have almost completely healed and were all able to discharge from the hospital within one month. The author hopes further more cases of ulcerative colitis be made trial with this drug
Title Of The Study: Clinical study on chronic gastritis (First Reports)
The pathophysiology of chronic gastritis remains to be determined. Metoclopramide sulpiride and y-Oryzanol, drugs which mainly act on the central nervous system, were reported to be effective against various complaints in patients with chronic gastritis. The aim of the present study was to In addition, the effects of these drugs on clinical evaluations were compared. Nineteen patients with chronic gastritis (aged 25 to 74 years), 21 men and 8 women were studied. All patients were orally given. Serum gastrin was determined by radioimmunoassay. The results obtained herein were as follows: a therapeutic dose of metoclopramide (30 mg / day), sulpiride (300 mg / day) and y-oryzanol (300 mg, day) for 4 weeks.1. Sixty two% of the patients was found to be neurotic, suggested by the method of modification of MI test.2. Various kinds of complaints were observed in patients with chronic gastritis. These include nausea, fatigability, and postpradial fullness and discomfort in The upperabdomen.3. The effective rates of metoclopramide, sulpiride and y-oryzanol against various complaints were 66.7%, 86.7% and 75.0%, respectively, It was of interest to note that sulpiride was the most effective against psychic complaints Administration of y-oryzanol resulted in decreased serum gastrin levels, while no change was observed in metoclopramide or sulpiride-treated groups.,5. No effect by these drugs on the rate of secretion of gastric juice was found.
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Title Of The Study: Clinical study on chronic gastritis(2nd report) – Endocrinological study of y-OZ effect
y-Oryzanol, ferulic acid ester of triterpenol extracted from rice-bran oil, has been used against autonomic instability with abdominal symptoms and climacteric complaints. Itaya et al. Postulated that monoaminergic neuron system involved in the anti-gastriculcerogenic action of this agent. In the first report, y-oryzanol was found to decrease serum gastrin levels in patients with chronic gastritis. These observations have led me design the present study to elucidate the endocrine effects of y-oryzanol in patients with chronic gastritis. Thirteen patients with chronic gastritis. The results shown here were as follows: were orally given a daily dose of y-oryzanol (300 mg / day) for 4 weeks. Seven healthy volunteers composed the control group.1. Administration of y-oryzanol to patients with chronic gastritis resulted in decreased serum gastrin levels, which was approximately 75% lower than the initial value. In contrast, there was no significant change in the serum gastrin levels as a group after administration of y -oryzanol to normal subjects.2. Arginine (0.5 g / k g , drip infusion over 30 min) -induced serum gastrin responses before and after y-oryzanol treatment were similar.3. No difference was observed in L-dopa (0.5 g) , orally) -induced gastrin response with or without y-oryzanol. However, serum HGH response to L-dopa was significantly suppressed by y-oryzanol.4. y-oryzanol failed to show discernible changes in serum levels of secret in, glucagon, catecholamine and prolactin. S. Baseline serum cortisol levels following y-oryzanol treatment were lower in all patients studied than the initial values without y-oryzanol. In contrast. The cortisol response to ACTH was not altered by y-oryzanol. Further more, the basal plasma ACTH levels appeared to be lowered by this agent. The lowering effect of y-oryzanol on serum gastrin level was clearly demonstrated inpatients with chronic gastritis, in a sharp contrast to control subjects. This suggests an increased susceptibility of the patients to y-oryzanol. The action of y-oryzanol on serum gastrin level may result from an effect on the hypothalamo-pituitary-adren alaxis. In addition, the present investigation provides evidence that y-oryzanol is antidopaminergic in the serum HGH response, as reported in metoclopramide and sulpiride.
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Title Of The Study: Clinical study of autonomic imbalance with abdominal symptoms: Effect of y-Oryzanol
300 mg of y-Oryzanol a day was administered to 21 patients who complained of autonomic instability including gastrointestinal symptoms, and they were observed for 2weeks.The results were as follow: 1) An improvement was observed in our subjects with regard to their gastrointestinal symptoms and other complaints. Particularly, in those patients who se symptoms were considered to be mild according to our check for autonomic functioning showed better improvement as compared with those whose symptoms were more serious.2) As for the effectiveness of y-Oryzanol, our result showed that it was markedly effective in 8 cases, effective in 5 cases, slightly effective in 5 cases and non-effective in 3 cases, indicating that it was either markedly effective or effective in 62% of the subjects.3) In the total assessment, the effectiveness of y-Oryzanol in the less seriously ill group was greater than that of more seriously ill group. y-Oryzanol was more effective in the patients who were over 40 years old than those who were less than 40.4) No side effect was observed in any patient.
Title Of The Study: Action of y-Oryzanol on various gastric juice secretion stimulants
In order to elucidate the gastric juice secretion inhibitory effect of y-Oryzanol, we investigated the effect of y-Oryzanol on histamine, carbachol, and tetra gastrin stimulation, and examined the involvement of vagus nerve and splanchnic nerve in the onset of the effect. As a result, when y-Oryzanol, 100 mg / kg, sc was continuously administered once a day for 5 days, suppression was observed in the latter half of the peak of histamine stimulation. No significant effect was observed on carbachol stimulation, and a clear suppression of the tetra gastrin stimulation effect was observed. This inhibitory effect disappeared with vagal amputation, but was not affected by visceral nerve amputation. From these facts, it seems that the gastric juice secretion inhibitory effect of y-oryzanol is largely related to the vagus nerve system rather than the visceral nervous system. We also inferred that the onset of this effect may be related to the catecholamine-increasing effect of y-oryzanol in the brain.
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Title Of The Study: Application of Oryzanol in Digestive System Diseases
Oryzanol (OZ for short) is extracted from rice bran oil and is a mixture of ferulic acid esters mainly composed of triterpene alcohols and sterols. In the past, OZ was mainly used for the treatment of cyclic psychosis, premenstrual tension, menopausal syndrome, vascular headache, sequelae of traumatic brain injury and autonomic dysfunction. With the deepening of its research, it was found that the drug has some new uses, which are summarized as follows. Treatment of gastroptosis Shan Chengwu et al. observed the curative effect of OZ on gastroptosis patients by double-blind method, taking 75mg every day, and after 3 weeks, the patients were self-sufficient.
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Title Of The Study: Clinical Experience of Medication for Stomach and Duodenal Ulcer in Department of Gastroenterology
To explore the clinical experience of medication for stomach and duodenal ulcer in department of gastroenterology.Methods:87 patients with gastric and duodenal ulcer were selected. They were randomly divided into the experimental group with 48 cases and the control group with 39 cases. The control group were treated with cimetidine, and the experimental group were treated with oryzanol combined with metronidazole, then we compared clinical curative effect of two groups. Results : In the experimental group, the effective rate was 100%,the incidence of adverse reactions was 2.1%,and the disease recurrence rate was 8.3%.The control group was 89.7%,43.6%,10.3% respectively. The differences were statistically significant(P<0.05). Conclusion: The clinical curative effect of oryzanol combined with metronidazole for treatment of stomach and duodenal ulcer was significant.
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Title Of The Study: Clinical Observation of Pinaverium Bromide Combined Oryzanol in Treatment of Irritable Bowel Syndrome
Objective: To observe the clinical efficacy of pinaverium bromide and oryzanol in the treatment of irritable bowel syndrome.Methods:58 patients with irritable bowel syndrome were randomly divided into observation group of 30 patients,28 patients in control group. Control group were given pinaverium bromide treatment, three times a day, each 50 mg. Observation group were treated on the basis of another given oryzanol treatment three times a day, each 30 mg.30-day cycle, observed the clinical effect.Results:30 patients observed total number of valid cases 29 cases, accounting for 96.67%,control group 28 patients, the total number of valid cases 20 cases, accounting for 71.43%.The total effective rate was significant difference(χ2=5.24,P<0.05).Observed significant efficiency(56.67%) compared with the control group, differences were statistically significant(χ2=5.99,P<0.05). And all patients had no obvious adverse reactions. Conclusion: Pinaverium bromide and oryzanol combination therapy is significantly effect, relapse, which should be clinical application.
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Title Of The Study: Clinical Research on Trimebutine Maleate, Oryzanol and Anisodamine Combined Application in Treatment of the Elderly Patients with Irritable Bowel Syndrome
Objective To observe the clinical effect of the combination of trimebutine, oryzanol and anisodamine in the treatment of irritable bowel syndrome (IBS) in the elderly. Methods 80 patients with IBS were randomly divided into a control group of 32 cases and an observation group of 48 cases. After trimebutine treatment, the observation group was treated with trimebutine, oryzanol, anisodamine, etc. The treatment effect and symptom scores after treatment were compared between the two groups. Results After treatment, the symptoms of the observation group were significantly improved in 31 cases (64.6%). ), 13 cases (27.1%) of symptoms were effectively improved, 4 cases (8.3%) of no improvement in symptoms, and the total symptom improvement rate was 91.7%; the control group…
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Title Of The Study: Clinical Study of The Application of Pinaverinm Bromide Combined with Oryzanol in The Treatment of Irritable Bowel Syndrome
Objective To investigate the therapeutic effect of pinaverium bromide combined with oryzanol on irritable bowel syndrome. Methods Ninety-two patients with irritable bowel syndrome were randomly divided into observation group and control group, 46 cases in each. The observation group was given pinaverium bromide combined with oryzanol , the control group was only given oryzanol, and the curative effects and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 95.7% (44/46), which was significantly higher than that of the control group (67.4% (31/46) (P ＜ 0.01). ); no obvious adverse reactions occurred in the two groups of patients during the treatment.
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Title Of The Study: Doxepin Tablets Combined with Oryzanol Tablets in the Treatment Of Refractory Irritable Bowel Syndrome of 7 Cases
Objective: To explore the effect of doxepin tablets combined with oryzanol tablets in the treatment of refractory irritable bowel syndrome.Methods:7 patients with refractory irritable bowel syndrome were selected,they were treated with doxepin tablets combined with oryzanol tablets,we observed the treatment effect.Results:At 3 months,4 cases were effective,3 cases were effective,at 6 months,6 cases were effective,1 case was effective,0 case was ineffective. Conclusion: The effect of doxepin tablets combined with oryzanol tablets in the treatment of refractory irritable bowel syndrome was better.
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Title Of The Study: Effect Of Oryzanol Combined With Trimebutine Maleate in Treating Irritable Bowel Syndrome
Objective To explore the effect of oryzanol combined with trimebutine maleate in treating irritable bowel syndrome(IBS).Methods A total of 67 patients with IBS were selected in the 33 / st Hospital of Zhuzhou from May 2012 to August 2014,according to the differences of the treatment measures,they were divided into the treatment group(35 cases) and control group(32 cases).Ccontrol group were given trimebutine maleate treatment,treatment group were given oryzanol treatment on the basis of control group.Before and after treatment,clinical effect,symptom score,frequency of symptoms score and incidence of adverse reactions were compared.Results The total effective rate of treatment group was higher than that of the control group(P < 0.01); before treatment,symptom scores and frequency of symptoms score showed no significant differences between the two groups(P > 0.05),after treatment,symptom scores and frequency of symptoms score of treatment were lower than those of control group(P < 0.05); incidence of adverse reactions showed no significant differences between the two groups(P > 0.05). Conclusion Oryzanol combined with trimebutine maleate has notable curative effect in the treatment of irritable bowel syndrome,can improve intestinal function,have less adverse reactions.
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Title Of The Study: High Dosage Oryzanol and Vitamin B_1 in The Treatment of Functional Dyspepsia
Objective To observe the clinical effect of high dosage Oryzanol and Vitamin B 1 on functional dyspepsia.Methods 86 patients accompany with disturbance in emotion were divided into treatment group and control group,the control group patients were individualization treatment with Mutinline、Ranitidine、Sucralfate、Hydrosulfites et al, the treatment group patients were given Oryzanol 100mg Tid and Vitamin B 1 100mg Tid for 8 weeks, except the individualization treatment. The final diagnosis of functional dyspepsia was based in “Rome standard”.Results In the treatment group the significant rate was 65.1% and the total utility rate was 51.1% while in control group the rates were 86.0% and 67.4%,respectively.No difference of the significant utility rate between the treatment group and control group(P>0.05).But the total utility rates were the significant difference between the two groups(P<0.05).Conclusions High dosage of Oryzanol and Vitamin B 1 can get good clinical effect in the treatment of functional dyspepsia.
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Title Of The Study: Influence Of Tongxie Sishen Decoction Combined With Trimebutine Maleate And Oryzanol On Serum Ifn-γ,5-ht,npy Levels And T Lymphocyte Subsets In Patients With Diarrhea Predominant Irritable Bowel Syndrome
To analyze the influence of Tongxie Sishen decoction combined with trimebutine maleate and oryzanol on serum interferon gamma(IFN-γ),5 hydroxytryptamine(5-HT),neuropeptide Y(NPY)levels and T lymphocyte subsets in the patients with diarrhea predominant irritable bowel syndrome(IBS-D).[Methods]Ninety-eight patients with IBS-D were selected and randomly divided into the control group and the observation group,forty-nine cases in each group,the control group were treated with trimebutine maleate and oryzanol treatment,on the basisof this,the observation group were treated with Tongxie Sishen decoction,the changes of TCM symptom scores before and after the treatment,clinical efficacy,the changes of IFN-γ,5-HT,NPY,T lymphocyte subsets levels and the incidence rate of adverse reactions were observed and recorded in the two groups.[Results]After treatment,the TCM symptom score of the observation group was significantly lower than that of the control group(P<0.05);the total effective rate of the observation group was significantly higher than that of the control group(P<0.05);the levels of IFN-γ,5-HT and NPY in the two groups were significantly decreased(P<0.05),and the changes of the indexes in the observation group were significantly higher than those in the control group(P<0.05);after treatment,the CD3~+,CD4~+levels and CD4~+/CD8~+of T lymphocyte subsets in the two groups were significantly increased(P<0.05),the CD8~+level decreased significantly(P<0.05),and the changes of the indexes in the observation group were greater than those in the control group(P<0.05);the incidence rate of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).[Conclusion]Tongxie Sishen decoction combined with trimebutine maleate and oryzanol in the treatment of IBS-D can effectively reduce the serum IFN-γ,5-HT and NPY levels,improve T lymphocyte CD3~+,CD4~+,CD8~+levels and CD4~+/CD8~+,and the risk of adverse reaction is low,the curative effect is significant.
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Title Of The Study: Meta-analysis on Trimebutine Maleate Combined with Oryzanol in Treating Irritable Bowel
To systematically evaluate the efficacy and safety of trimebutine maleate combined with oryzanol in treating irritable bowel syndrome(IBS). METHODS Randomized controlled trials(RCTs) of trimebutine maleate combined with oryzanol in treating IBS were identified by searching electronic databases including Cochrane Library, Springer Link, CNKI, PubMed, Embase, CBM, Wanfang Data and VIP Database. Two reviewers extracted data independently and assessed literature quality according to the Cochrane Collaboration Risk Assessment Criteria and meta-analysis was conducted by using RevMan 5.3 software. RESULTS A total of 15 RCTs were included, involving 1 338 patients. The results of meta-analysis showed that compared with the control group, trimebutine maleate combined with oryzanol had better clinical efficacy [RR=1.26, 95%CI(1.20, 1.33), P<0.000 01], and improved clinical symptoms, abdominal pain [SMD=-0.94, 95%CI(-1.22, -0.66), P<0.000 01], diarrhea [SMD=-1.33, 95%CI(-1.68, -0.98), P<0.000 01], daily average number of bowel movements [SMD=-1.41, 95%CI(-1.79, -1.03), P<0.000 01], abnormal proportion of stool characteristics [SMD=-2.82, 95%CI(-3.42, -2.22), P<0.000 01)], and reduced adverse reactions [RR=0.40, 95%CI(0.27, 0.60), P<0.000 1] in the treatment of IBS. CONCLUSION Trimebutine maleate combined with oryzanol has better clinical efficacy and lower adverse reactions compared with trimebutine maleate in the treatment of IBS.
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Title Of The Study: Observation of The Curative Effects of Oryzanol Treating Peptic Ulcer
Objective To observe the clinical efficacy of oryzanol in the treatment of peptic ulcer. Methods 60 patients with peptic ulcer were treated with omeprazole, axicillin and metronidazole orally as the control group, and the treatment combination was with oryzanol. Results The difference between the treatment group and the control group was The total effective rate and HP clearance rate were 95.00%, 81.67% and 95.00%, 83.33%, respectively, and the differences were statistically significant (P<0.05). Conclusion Oryzanol is effective and safe in the treatment of peptic ulcer.
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Title Of The Study: Ao Mei La Zuo Mo Sha Bi Li Lian He Gu Wei Su Zhi Liao Gong Neng Xing Xiao Hua Bu Liang De Liao Xiao Guan Cha
Objective To observe the curative effect of omeprazole, mosapride combined with oryzanol in the treatment of functional dyspepsia. Methods Ninety-six patients diagnosed with functional dyspepsia were randomly divided into the combined treatment group and the omemoza group, with 48 cases in each group. The omeprazole group was treated with omeprazole (20 mg, once/d) combined with mosapride (5 mg, 3 times/d). The combined treatment group was treated with oryzanol (30 mg, 3 times) on the above basis. /d) Treatment. After 4 weeks of treatment, the improvement of symptoms in the two groups was observed and the curative effects were compared. Results After treatment, the symptoms of upper abdominal distension, abdominal pain, early satiety, belching, nausea, nausea, vomiting, loss of appetite and other symptoms in the two groups were significantly higher than those in the two groups. There were significant improvements before treatment (P < 0.01 or P < 0.05), and the effect of the combined treatment group was more significant than that of the omemox group (P < 0.01). The effect of the combined treatment group was better than that of the omemox group (Hc =6.188, P＜0.05). Conclusion Omeprazole, mosapride combined with oryzanol has a good curative effect in the treatment of functional dyspepsia.
Title Of The Study: Research of the Clinical Effect of Trimebutine and Oryzanol as a Treatment on Patients with Irritable Bowel Syndrome
Objective To observe the clinical effect of trimebutine maleate capsules,oryzanol joint Compound Eosinophil-Lactobacillus tablets treating the patients with irritable bowel syndrome. Methods 120 cases of irritable bowel syndrome,60 cases in the treatment group,60 cases in the control group. The treatment group received trimebutine maleate,oryzanol and Compound Eosinophil-Lactobacillus,the control group only received trimebutine maleate and oryzanol. Results The total effective rate of the treatment group was 86.67% and control group was 71.67%,the total effective rate of the two groups were statistically significant differences in their efficacy(P<0.05). Conclusion Trimebutine maleate capsules,oryzanol joint compound Lactobacillus acidophilus tablets in the treatment of IBS have a significant effect,with better compliance and fewer side effects. It is significantly better than trimebutine maleate capsules single joint oryzanol treatment,and it is worth to promote and apply.
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Title Of The Study: The Effect of Doxepin Combined with Oryzanol for Irritable Bowel Syndrome
Objective To evaluate the effect of Doxepin combined with Oryzanol for irritable bowel syndrome. Methods One hundred and twenty patients with irritable bowel syndrome who were treated in the Armed Police General Hospital from August 2015 to October 2017 were randomly divided into observation group (n=60)and control group (n=60)using random number table method. The observation group received Doxepin combined with Oryzanol for treatment,while control group received Dicetel. Both groups were given psychological care. The clinical effect,adverse events and the improvement of mental state were compared between the two groups. Results The total clinical effective rate of ob-servation group (95.0％)was significantly higher than control group (83.3％)(χ2=4.23,P<0.05). Adverse reaction rate of observation group was slightly higher than that of control group (χ2=0.15,P>0.05). After 6 weeks of treatment,the psychological quantitative score of the observation group was significantly lower than that of the control group. Conclusion : The effect of Doxepin combined with Oryzanol for irritable bowel syndrome is superior to that of Dicetel. The incidence of adverse reactions of Doxepin combined with Oryzanol was roughly equal to that of Dicetel. Meanwhile,Doxepin combined with Oryzanol can effectively improve the patient’s mental state.
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Title Of The Study: The Effect of Irritable Bowel Syndrome Patients with Application Of bifidobacterium Tetravaccine Tablets and Oryzanol
Objective To explore the effect of irritable bowel syndrome patients with application of bifidobacterium tetravac?cine tablets( live) and oryzanol. Methods 384 cases of patients with irritable bowel syndrome were selected and randomly divided into two groups. Control group gave pinaverium bromide and oryzanol, and the experimental group used bifidobacterium tetravaccine tablets ( live) on the basis of control group. Mental score, enteron symptom scores, therapeutic effect and adverse reactions were detected be?fore and after treatment and compared between two groups. Results After treatment, patients with anxiety scale, depression rating scale and the digestive tract symptom scores were lower than before treatment in the two groups ( P<0.05) . After treatment, anxiety rat?ing scale, depression rating scale and the digestive tract symptom scores of the experimental group were significantly lower than control group ( P<0.05) . The total effective rate of control group was 71. 88%, the experimental group was 90. 63%, and the experimental group was significantly higher than control group (P<0.05).Two groups had mild adverse reactions, and the control group had 4 cases with headache and weakness, 2 case with nausea;the experimental group had 2 case with headaches, fatigue and 2 case with nausea. The adverse reaction were disappeared after symptomatic treatment. Conclusion : Irritable bowel syndrome patients with application of bifidobacterium tetravaccine tablets( live) joint oryzanol has obvious therapeutic effect, less adverse reactions, and it is worthy of clinical promotion.
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Title Of The Study: The Efficacy of Treatment of Peptic Ulcer by Oryzanol
Objective To observe the clinical efficacy of oryzanol in the treatment of peptic ulcer. Methods 120 patients with peptic ulcer were treated with omeprazole, amoxicillin and metronidazole orally as the control group, and the treatment combination was with oryzanol. Results The total effective rate of the treatment group was as follows: Compared with the control group, the total effective rate and HP elimination rate were 95.00% and 81.67% respectively, and the difference was statistically significant (P<0.05). Conclusion Oryzanol is effective and safe in the treatment of peptic ulcer.
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Title Of The Study: The Clinical effect Observation of Pinaverium Bromide Combined with Oryzanol on Elderly Patients with Intestinal Irritable Syndrome
Objective To observe t clinical effect observation of pinaverium bromide combined with oryzanol on elderly patients with intestinal irritable syndrome. Methods 40 elderly patients with intestinal irritable syndrome were selected and randomly divided into observation group and control group. Two groups of patients were given psychological nursing, diet intervention, the observation group was given pinaverium bromide combined with oryzanol, the control group were treated with pinaverium bromide. Two groups of patients were treated for 30 days. Clinical effect were evaluated after treatment. Results The significant efficiency、effective rate, less efficient, total effective rate in the observation group was 85%, 10%, 5%, 95%; The significant efficiency、effective rate、less efficient, total effective rate in the control group was50.0%、15.0%、25.0%、65.0%.The total effective rate of the observation group was higher than that in the control group, the difference was statistically significant (χ2=3.90, P<0.05). Conclusion Pinaverium bromide combined with oryzanol in treatment of elderly patients with irritable bowel syndrome clinical effect is significant, the therapy should be the reference for doctors.
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Title Of The Study: Trimebutine Maleate Combined with Oryzanol in the Treatment of Intestinal Clinical Efficacy and Safety of Irritable Bowel Syndrome
Objective To evaluate trimebutine maleate combined with oryzanol in treatment of irritable bowel syndrome efficacy and safety. Methods We selected 50 cases of patients with irritable bowel syndrome, the patients were randomly divided into observation group and control group, each 25 cases, observation combined with oryzanol treated with trimebutine maleate group of patients, the control group was treated with trimebutine maleate in the treatment of patients, treatment effects were compared between the two groups. Results Patients in the observation group treatment is better than the control group, and the adverse reaction is lower than that of the control group,t he difference was statistically significant(P < 0.05).Conclusion Trimebutine maleate combined with oryzanol in treatment of irritable bowel syndrome can effectively improve the effect, and high safety.
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Title Of The Study: Observation on Super-measuring Oryzanol in Association with Propantheline Bromide to Turnthe Funtion that Cures IBS
To observe the effect of supernormal dose of oryzanol combined with propencin bromide in the treatment of irritable bowel syndrome (IBS). Methods: All patients stopped other drugs before treatment, avoided irritating food intake, and established a reasonable and regular lifestyle 48 cases in the observation group were given oryzanol 100 mg and 15 mg propencin bromide, 3 times/d orally; 46 cases in the control group were given 2 tablets of compound phenepiperidine, 3 times/d. 3 weeks were the final results. Results: The total effective rate of the observation group was 87.5%, and that of the control group was 56.5%. The comparison between the two groups was statistically (P<0.05). Conclusion: The combination of the two drugs The treatment of IBS is better than the traditional prescription astringent and anti diarrheal drug treatment, and there is no obvious toxic and side effects.
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Title Of The Study: Observation on The Curative Effect of Helicobacterpylori Positive Chronic Gastritis Treated Bb Erythromycin, Furazolidone and Oryzanol
Objective To observe the curative effect of erythromycin, furazolidone and oryzanol inthe treatment of Helicobacter pylori (HP) positive chronic gastritis. Method The treatment groupwas given oral erythromycin, furazolidone and oryzanol, and the control group was givenomeprazole and metronidazole orally. Compared with amoxicillin and amoxicillin. Results The totaleffective rate of improvement of clinical symptoms and gastroscopic lesions in the treatmentgroup was higher than that in the control group (P<0.05, P<0.05). The reaction in the controlgroup was significantly higher than that in the treatment group (P<0.01). Conclusion Erythromycin,furazolidone and oryzanol in the treatment of Helicobacter pylori-positive chronic gastritis aremore effective than triple therapy with omeprazole, metronidazole and amoxicillin, and theadverse reactions It is less effective in clearing Helicobacter pylori infection.
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Title Of The Study: Application Observation of Trimebutine Maleate combined with Oryzanol in Irritable Bowel syndrome
Objective To investigate the application of trimebutine maleate combined with oryzanol in irritable bowel syndrome. Methods A total of 198 cases of irritable bowel syndrome diagnosed and treated from January 2009 to January 2011 were randomly divided into a treatment group of 108cases and a routine group of 90 cases. The clinical efficacy of the two groups was observed. Results The total effective rate of the treatment group was 91.66%, which was significantly better than that of the conventional group, which was 71.11%. The total effective rate of the two groups was P<0.05, and there was a significant difference. Conclusion Trimebutine maleate combined with oryzanol in the treatment of irritable bowel syndrome can regulate the visceral autonomic nervous system, regulate gastrointestinal motility in both directions, improve clinical symptoms, and promote disease recovery.
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Title Of The Study: Clinical effect of Treatment of Adjuvant Psychological Intervention of Pinaverium bromide combined with Oryzanol to Elderly Patients with Irritable Bowel Syndrome
Objective To investigate whether psychological intervention has auxiliary clinical effect on pinaverium bromide combined with oryzanol in the treatment of elderly irritable bowel syndrome. Methods 84 elderly patients with irritable bowel syndrome were randomly divided into the control group and the treatment group, and the control group received Pinaveri The treatment group was treated with ammonium bromide combined with oryzanol, and the treatment group implemented psychological intervention on this basis. The treatment efficiency, symptom improvement and psychological state of the two groups were compared and statistically analyzed. Results The total effective rate of the treatment group was 90.5%. The total effective rate in the control group was 71.4%, P=0.026. The improvement of symptoms of irritable bowel syndrome in the treatment group was significantly better than that in the control group, P<0.05The negative psychological score (SDS, SAS) in the treatment group was significantly lower than that in the control group, P < 0.05. Conclusion Psychological intervention on the basis of pinaverium bromide combined with oryzanol is helpful to improve the clinical effect of irritable bowel syndrome in the elderly.
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Title Of The Study: Observation on the Treatment Efficacy of Nifedipine Combined with Oryzanol Against Non-constipated Irritable Bowel Syndrome
Objective To investigate nifedipine combined with oryzanol in the treatment of non-constipation irritable bowel syndrome. Methods 73 cases of non-constipation irritable bowel syndrome were randomly divided into three groups, control group (I) 23 cases, nifedipine 10mgalone, 3 times/d, orally; 20 cases in the control group (11), 30 mg oryzanol alone, 3 times/d, orally;30 cases in the treatment group, 10 mg nifedipine, 3 times/d orally, combined with oryzanol 30mg, 3 times/d The three groups of patients used it for 4 consecutive weeks. Results After 4 weeks of medication in the control group (I, I), the total effective rates of various discomfort symptoms were significantly improved, and the average total effective rates were 34.7% and 36.4%,respectively. The average efficiency reached 79.1%. Conclusion: Continuous use of nifedipine combined with oryzanol in the treatment of non-constipation irritable bowel syndrome is more effective.
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Title Of The Study: Study on the Influence of Bifidobacterium Quadruplex Combined with Oryzanol on Serum Levels of TNF-a, IL-6 in Female Patients with Irritable Bowel Syndrome
To investigate the efficacy of Bifidobacterium quadruple viable bacteria combined with oryzanol in the treatment of female irritable bowel syndrome and its effect on serum TNF-a andIL-6. [Method] 86 patients with irritable bowel syndrome were randomized Divided into two groups,43 cases in each group. Control group: received routine supportive treatment. Observation group: On the basis of routine treatment of control group, oryzanol and quadruple viable bacteria of bifidobacteria were added. and inflammatory factor levels Y Results] The total effective rate of the observation group was 95.35% higher than that of the control group, 72.09%, and the difference was statistically significant (P<0.01). After treatment, the severity of symptoms and frequency of symptoms in the observation group were The scores were lower than those in the control group, and the differences were statistically significant (P<0.01). After treatment, the Hamilton Depression Scale (HAMD) score in the observation group was (10.41‡2.50) and the Hamilton Anxiety Scale (HAMA) score (The score of 10.24=2.68) was lower than the HAMD score(12,92+3.16) and HAMA score (12.63+3.35) of the control group, and the difference was statistically significant (P<0.01). After treatment, the serum TNF-a level of the observation group(29.72 +11.75) pg./mL, IL-6 (11.23 + 3.15) ng/L were lower than the control group serum TNF-a levels (43.56 ‡ 12.47) pg/mL, IL-6 (17.91 ‡ 4.17) ng/L, the difference There were statistical significance (P<0.01). Conclusion: Bifidobacterium quadruple viable bacteria combined with oryzanol is effective in the treatment of irritable bowel syndrome, and can effectively improve gastrointestinal function and serum TNF-a, IL-6 level and improve the quality of life of patients.
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Title Of The Study: Clinical Observation Of Tetralogy Of Viablebifidobacterium Combined With Oryzanol Treatment for Irritable Bowel Syndrome
Objective To investigate the clinical efficacy of Bifidobacterium quadruple viable bacteria combined with oryzanol in the treatment of irritable bowel syndrome. Methods Sixty-eight patients with irritable bowel syndrome were randomly divided into an observation group and a control group, the observation group was given 1.5 g of bifidobacteria quadruple viable bacteria tablets, orally, 3 times/d. The course of treatment for both groups was 12 weeks. Results The total effective rate was 94.12% in the observation group and 76.47% in the control group. The clinical efficacy of the two groups of patients was compared, and the difference was statistically significant(P<0.05). After treatment, the clinical gastrointestinal symptom scores of the two groups were significantly improved compared with those before treatment, and the difference was statistically treatment, the scores of Hamilton Depression Scale and Anxiety Scale in the two groups were significantly improved compared with those before treatment, and the difference was statistically significant (P<0.01). It was significantly better than the control group, and the difference between the two groups was statistically significant (P<0.05). Conclusion: Bifidobacterium quadruple viable bacteria combined with oryzanol in the treatment of irritable bowel syndrome has a positive effect, and in the process of combined treatment, no obvious toxic and side effects were found, all safety indicators were normal, and the tolerance and safety were good.
Title Of The Study: Clinical Effect by viable Bifidobacterium Tetravaccine Combined with Oryzanol in the Treatment of Irritable Bowel Syndrome
Objective To investigate the clinical effect of Bifidobacterium quadruple viable bacteria combined with oryzanol on irritable bowel syndrome. Methods 52 patients with irritable bowel syndrome were randomly divided into the observation group (28 cases) and the control group ( 24cases). Both groups of patients received oral administration of pinaverium bromide after out patient treatment. On this basis, the observation group was treated with Bifidobacterium quadruple viable bacteria combined with oryzanol, and the control group was treated with oryzanol. The treatment of the two groups of patients was compared. effect, mental state and occurrence of adver sereactions. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (y2=4.3797, P<0.05). After treatment, the Hamilton Depression Scale (HAMD) score in the observation group was (10.1‡2.3)points, lower than the control group (12.7+3.4) points, the difference was statistically significant(=3.2691, P<0.05); the Hamilton Anxiety Scale (HAMA) score of the observation group was(9.9+2.6) ) score, which was lower than that of the control group (12.1+2.9), and the difference was statistically significant (=2.8842, P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
Conclusion: The addition of f-Bifidobacterium quadruple viable bacteria combined with oryzanol in the clinical treatment of irritable bowel syndrome has a good clinical effect, and the method is worth learning.
Title Of The Study: High dosage Oryzanol and Vitamin B1 in the Treatment of Functional Dyspepsia
Objective To investigate the efficacy of high-dose oryzanol and vitamin B1 on functional dyspepsia (FD) and patients with emotional disorders. Methods 86 patients who were diagnosed with FD according to the “Rome criteria” and accompanied by obvious depression and anxiety were randomly divided into two groups. The treatment group and the control group were given conventional treatments such as morphine, ranitidine, sucralfate or aluminum magnesium carbonate according to the principle of individualized treatment. In addition to the above conventional treatments, the treatment group was also given psychological counseling and high-dose oryzanol. and vitamin B1, 100 mg each, 3 times/d, 8 weeks as a course of treatment. The curative effect was evaluated according to the change of symptom score. Results The markedly effective rate and total effective rate of the treatment group after 8 weeks of treatment were 65.1%and 86.0%, respectively, while the control group The difference was 51.1% and 67.4%. After statistical analysis, there was no significant difference in the significant rate between the two groups (P>0.05), but there was a significant difference in the total effective rate (P<0.05). Conclusion The combination of high-dose oryzanol and vitamin B1 Psychological and conventional drug treatment for FD patients with depression and anxiety can promote the relief of clinical symptoms and the improvement of mental state, and there are no other side effects caused by increasing the dosage.
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Title Of The Study: Study on the efficacy of the combined regimen of nifedipine and oryzanol in the clinical treatment of children with functional abdominal pain
Objective To study the efficacy of nifedipine and oryzanol in the treatment of functional abdominal pain in children and to explore its clinical applicability. Methods A total of 78 children with functional abdominal pain treated in our hospital from October 2013 to September 2014 were selected as the rescarch subjects and randomly divided into the experimental group (n=35) and the control group (n= 43). The children in the experimental group were treated with nifedipine combined with oryzanol tablets, while those in the control group were treated with oryzanol tablets. The incidence rate and degree of abdominal pain and other clinical symptoms were observed and recorded to compare the treatment efficiency. Results The effective rate was 91.3% in the experimental group and 53.4% in the control group. The clinical efficacy of the experimental group was significantly better than that of the control group. The differences were statistically significant. (P<0.05). Conclusion Nifedipine combined with oryzanol tablets has a more significant therapeutic effect on children with functional abdominal pain, which has a synergism and strengthening effect, and is worthy of clinical application.
