Clinical Trials on
Gamma Oryzanol & Formulations With Gamma Oryzanol As The Active Ingredient On Miscellaneous Issues Like Globus Pharyngeus, Hearing Issues, Lump In Throat, skin diseases, kidney diseases, hearing issues, burning mouth syndrome etc.
Title Of The Study: Effect of y-Oryzanol (y-0Z) on laryngeal neurosis
The effect of y-Oryzanol (y-OZ) on the lump in throat (Hypo pharynx-neurosis) was studied in 30 cases. The dosage of the agent was 9 tablets a day and it was administered continuously in2 to 4 weeks.7% sodium bicarbonate solution (50-250cc) was simultaneously administered intravenously in all cases. The complain was completely removed in 14 cases (46.7%); improved in 9 cases(30%); no change was seen in 7 cases (23.3%)No case was aggravated by the treatment and there was no marked side effect.
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Title Of The Study: Effect of y-Oryzanol on neurological deafness and tinnitus(1st report)
We treated 30 patients suffering from perceptive deafness and tinnitus with ‘y-Oryzanol’ for 2 to 8 weeks (in daily doses of 30mg). As following tables, we had considerably good results but observed no remarkable side effects.
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Title Of The Study: Acute low-tone sensorine sensorine deafness
Three hundred and eighty-four patients with acute low-tone sensorine ural hearing loss (ALSH) who consulted my clinic from 1987 to 2001 are herein retrospectively investigated. The results are as follows. 1) In 1999, I reported that the number of ALSH patients had gradually increased from 1987to 1996. This tendency continued from 1997 to 2001. 2) The number of female patients continued to increase while, on the other hand, the number of male patients showed no significant increase. 3) Of the 212 patients, 81.1% and 6.6% showed a complete and partial recovery of hearing, respectively.4) A etiologically, ALSH may be due to a dysfunction in either the autonomic nervous system or a hormone in balance in the patients probably caused by some type of social anxiety. 5) Comparing the therapeutic effects of y-oryzanol, is osorbide and steroids on ALSH, y-oryzanol showed the best results, 6) The patients whose hearing level in high frequency regions decreased tended to show a poor recovery, 7) Recently, the recovery rate of ALSH is gradually declining. This is considered to be due to the increase in the number of patients whose hearing levels in high frequency regions decreased.
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Title Of The Study: Clinical trial of Heizet Tablets 50 (y-oryzanol) for globuspharyngis
The abnormal sensation of the pharyngolaryngeal region might be considered to depend on various factors which affect each other. A disorder of the autonomic nervous system may be the most important one. Hi-Z tablet (gamma-oryzanol), which seems to act on the hypothalamus, that is a center of internal endocritic sensation and of the autonomic nervous system, was found to be effective for the abnormal sensation of the pharyngolaryngeal region.
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Title Of The Study: Clinical Effect Of Self-create Prescription Of Traditional Chinese Medicine Gargle And Oryzanol-riboflavin-vitamin E In The Treatment Of Burning Mouth Syndrome
Objective To observe the clinical effect of self-create prescription of traditional Chinese medicine gargle and oryzanol-riboflavin-Vitamin E in the treatment of burning mouth syndrome(BMS). Methods The clinical data of 80 patients with BMS treated in the outpatient department of the stomatological medical center of Foshan hospital of TCM from June 2017 to December 2019 were collected, and the patients were divided into treatment group and control group according to the method of random number table, with 40 cases in each group. The treatment group was treated with selfcreate prescription of traditional Chinese medicine gargle+oryzanol-riboflavin-Vitamin E, and the control group was treated with normal saline gargle+oryzanol-riboflavin-Vitamin E. The degree of pain improvement before and after treatment was compared between the two groups. Results Before treatment, there was no significant difference in VAS score between the two groups(P>0.05). After 2 weeks of treatment, the VAS scores of patients in both groups significantly reduced, and that in the treatment group was lower than the control group, and the differences were statistically significant(P <0.05).Conclusion : Compared with western medicine alone, the self-create prescription of traditional Chinese medicine gargle and oryzanol-riboflavin-Vitamin E has a significant effect on relieving the pain of oral mucosa in patients with BMS.
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Title Of The Study: Effectiveness of Oryzanol in the Treatment of Clozapine-induced Salivation Reaction
80 patients with salivation induced by clozapine were randomly divided into two groups with 40 cases in each group. The observation group was treated with oryzanol tablets to antagonize salivation, and the control group was treated with placebo. And no adverse reactions of oryzanol were found. It is suggested that oryzanol can safely and effectively antagonize the salivation reaction caused by clozapine in psychotic patients.
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Title Of The Study: Therapeutic Effect of Mezolin Combined with Oryzanol
on Child Anorexia Pollakiuria
Objective To explore the treatment methods of neurogenic urinary frequency in children. Methods64 children with neurogenic urinary frequency were randomly divided into two groups, and they were treated with oral indomethacin combined with oryzanol and oral cephalexin capsules, and the efficacy was observed. Results Indomethacin combined with The markedly effective rate in the oryzanol treatment group was 93.75%; the markedly effective rate in the cephalexin capsules treatment group was 46.86%, and the difference was significant (P<0.01). Conclusion Indomethacin combined with oryzanol has a high curative effect in the treatment of children with neurogenic urinary frequency, with a short course of treatment and no obvious effect. side effects, worthy of clinical promotion.
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Title Of The Study: Analysis of Nine Patients with Marshall-White Syndrome
Of 9 patients with Marshall-White Syndrome, four patients had poor sleep quality, 4were stressed frequently, chest congestion and flustered, 2 ha sinus tachycardia. The lesions and sleep qualities of 4 patients were improved through the treating of oryzanol and psychological counseling. Neuropsychiatric factors leading to the capillary dysfunction may be the main causative factors in Marshall-White Syndrome.
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Title Of The Study: The Rapeutic Effect of Different Doses of Prednisone Combined with Oryzanol and Mecobalamin on Tinnitus without Hearing Loss
Objective To investigate the application effect of different doses of prednisone combined with oryzanol and mecobalamin in the treatment of tinnitus patients without hearing changes. Methods90 patients (133 ears) with tinnitus without hearing changes who received treatment from January2017 to December 2020 were selected, according to the random number table method, they were equally divided into three groups, A, B, and C, with 30 patients in each group. All three groups received oryzanol combined with mecobalamin, while group A (30 patients, 51 ears) received 0.2ml/d prednisolone per ear, group B (30 cases, 50 ears) added 0.5 ml/d prednisolone, and group C(30 cases, 32 ears) added 0.7 ml/d prednisone The three groups of patients were treated for 20days. The total effective rates of the three groups of patients were compared. Before treatment, on the 10th day of treatment and on the 20th day of treatment, the tinnitus and disability assessment scale (THI) scores of the three groups of patients were compared. The tinnitus symptom control rate was compared, and the incidence of adverse reactions during treatment was compared among the three groups. Results 1 The total effective rate of patients in group A was 78.43%(40/51), the total effective rate of patients in group B was 92.00% (46/50), The total effective rate of patients in group C was 93.75% (30/32), the three groups were significantly better than those in group B and group C (P<0.05), and there was no significant difference between two groups(P>0.05). ); @Comparing the THI scores of the three groups before treatment, the difference was not statistically significant (P>0.05). Group C was better than group A (P<0.05); Comparison found that the control rate of tinnitus in groups B and C at different times was better than that in group A (P<0.05); @The incidence of adverse reactions in group A was 15.69% (8/ 51), group B was 16.00% (8/50), group C was 28.13% (9/32), and group C was higher than that of groups A and B (P<0.05). Conclusion : The use of 0.5 ml/d prednisone Long guaner combined with oryzanol land methylcobalamin has a good therapeutic effect on patients with tinnitus without hearing changes, can significantly improve the clinical symptoms of patients, and also has a lower incidence of adverse reactions.
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Title Of The Study: Clinical effect of Anethol Trithione combined with Oryzanol, Vitamin B2, Vitamin E on burning Mouth Syndrome
Objective To investigate the clinical efficacy of anistrisulfide combined with oryzanol, vitamin B2and vitamin E in the treatment of burning mouth syndrome (BMS). Methods 54 patients with burning mouth syndrome were randomly divided into anistrisulfide group and routine group, 28cases in each. The group received conventional treatment with oryzanol, vitamin B2 and vitamin E, while the anisitrazine group received the combined treatment of oryzanol, vitamin B2 and vitamin E. The non-irritating salivary flow rate, dry mouth and burning pain were observed and compared between the two groups before and after treatment., and monitor the occurrence of adverse drug reactions during the treatment. Results In the 2nd and 4th week of treatment, the non-irritating salivary flow rate in the anisitrazine group was higher than that in the pre-treatment and routine groups, and the difference was statistically significant (P<0.05). In the 2nd and 4thweek of treatment, the visual analogue scale (VAS) scores of the two groups were lower than those before treatment, and the VAS scores of the anistrisulfide group were (4.51‡0.74) and(3.05‡1.03) lower than those of the routine group The scores of (5.27‡0.94) and (4.23‡0.52) were statistically significant (P<0.05). In the 2nd and 4th week of treatment, the dry mouth score in the anisitrazine group was lower than that in the pre-treatment and routine groups, and the difference was statistically significant. The clinical significance (P<0.05). Conclusion The efficacy of anisetrisulfide combined with oryzanol, vitamin B2 and vitamin E in the treatment of burning mouth syndrome is better than conventional treatment, especially for patients with dry mouth.
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Title Of The Study: Randomized Parallel Controlled Study of Bupi Yishen Decoction Combined with Adenosine Triphosphate+ Oryzanol in the Treatment of Chronic Fatique Syndrome of Spleen-Kidney Yang
[Objective] To observe the efficacy of Bupi Yishen Decoction combined with adenosine triphosphate + oryzanol in the treatment of chronic fatique syndrome due to spleen and kidney yang deficiency. [Method] Using a randomized parallel control method, 140 outpatients were randomly divided into two groups according to the order of treatment. Control Group 70 cases of adenosine triphosphate, 60 mg/time, 3 times/d; oryzanol, 20mg/time, 3 times/d. Treatment group70 cases of Pi Yishen Decoction (red ginseng 10g, Atractylodes fry 30g, Rhodiola rosea 15g, Yunling 12g, Dodder 15g, Psoralea 20g, tangerine peel 12g, dogwood meat yam each15g, Qing Pinellia, licorice and Bupleurum 10g each; wet Sheng Shichangpu Atractylodes; Add Zao Ren fried, Polygala; Depression plus Acacia flower, Bergamot); 1 dose/d, decocted in 400 mL of water, warm before breakfast and dinner: Western medicine treatment was the same as the control group. Continuous treatment for 10 d was a course of treatment. Clinical symptoms and adverse reactions were observed. The curative effect was determined by continuous treatment for3 courses. (Results] In the treatment group, 12 cases were cured, 23 cases were markedly effective, 24 cases were effective, 11 cases were ineffective, and the total effective rate was84.29%; in the control group, 12 cases were cured, 15 cases were markedly effective, 16 cases were effective, and 16 were ineffective. 27 cases, the total effective rate was 61.53%; the curative effect of the treatment group was better than that of the control group (P<0.05). [Conclusion] Bupi Yishen Decoction combined with adenosine triphosphate + oryzanol in the treatment of chronic spleen-kidney yang deficiency syndrome with satisfactory curative effect and no serious Adverse reactions are worth promoting.
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Title Of The Study: Clinical observe of effect of Regulating Hyperlipidemia and Weight Reduction by Berberine and Oryzanol
Objective: To study the effect of berberine hydrochloride (Ber) and oryzanol on blood lipid and body weight in patients with dyslipidemia. Methods: Divided 109 patients with cardiovascular disease with dyslipidemia into a treatment group (68 cases) and a control group (41 cases) The treatment group was treated with Ber and oryzanol, and the control group was treated with simvastatin; plasma TC, TG, LDL-C, HDL-C, blood glucose (BG), apolipoprotein B (apo-B) measured before and after treatment in both groups ), liver and kidney function and body weight. Result: The plasma concentration of TC,TG, LDL-C, BG and apo-B in the treatment group were significantly increased by (6.25‡0.19), (3.24‡0.25), (3.78*0.13), (7.56+0.6) mmol/Land(1.01+0.09) g/L decreased to (4.51+0.09), (1.80‡0.12), (2.82+0.10), (6.16+0.29) mmol/Land(0.77+0.23) g/L, the difference was statistically significant before and after treatment (P<0.01);there was no significant effect on renal function before and after treatment (P>0.05), and 18 cases with abnormal transaminase and other abnormalities were significantly improved to normal. 2There was no significant difference in the curative effect of lowering TC between the two groups(P>0.05), but there was a statistically significant difference in lowering TG (P<0.01). Among the 41cases with BMI ≥ 25 in the treatment group, 34 cases of weight were reduced from those before treatment (P<0.01). 71.75+1.88) kg decreased to (66.63+1.83) kg after treatment (P<0.01).Among them, 20 cases had weight loss 25 kg, and there was no obvious adverse reaction; there was no significant difference in the weight of the control group before and after treatment.(P>0.05). Conclusion: It not only has significant effect on reducing TC, TG, LDL-C, BG, apo-B, but also has a significant effect on obesity treatment. It is an efficient, cheap and safe lipid regulating and weight-loss drug.
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Title Of The Study: Observation of the Efficacy Of Oryzanol in Patients with Diabetic Peripheral Neuropathy
Objective To observe the efficacy of oryzanol in the treatment of diabetic peripheral neuropathy. Methods 152 patients with diabetic peripheral neuropathy treated in our hospital from July 2019 to January 2020 were retrospectively analyzed and divided into two groups according to different treatment methods, with 76 patients in each group. The control group was given routine treatment, the study group was given oryzanol treatment on the basis of the above, and the changes of VAS score, ankle-brachial function score, quality of life score, oxidative stress level, MCV, and total effective rate of treatment were observed in the two groups before and after treatment. . Results Before treatment, there was no significant difference in VAS score, ankle-brachial function score and ADL score between the two groups (P>0.05). There was no significant difference in SOD and TAOC levels between the two groups before treatment (P>0.05). ), there was no significant difference in SCV and NCV between the two groups before treatment (P>0.05); after treatment, the VAS score of the study group was lower than that of the control group, and the difference was statistically significant (P<0.05)., ADL scores were higher than those in the control group, the difference was statistically significant (P<0.05). After treatment, the SOD and TAOC levels in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). The SCV and CV in the study group after treatment The conduction velocity was faster than that of the control group, and the difference was statistically significant (P<0.05).The total effective rate of the study group was 94.74%, which was higher than 80.26% of the control group, and the difference was statistically significant (P<0.05). Conclusion Patients with peripheral neuropathy can be treated with oryzanol, which can effectively improve the pain of patients, improve the quality of life of patients, and improve the level of oxidative stress inpatients, which is worthy of application.
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