Clinical Trials on
Gamma Oryzanol & formulations with Gamma Oryzanol as the active ingredient on relieving menopausal symptoms
Title Of The Study: Effect of Mild Moxibustion on Menopausal Syndrome Patients with Yin Deficiency in Sex Hormone Level and Stress Situation
Objective: To explore the effect of mild moxibustion on menopausal syndrome patients with yin deficiency in sex hormone level and stress situation. Methods: 60 cases were ramdomly divided into moxibustion group and oryzanol group with 30 cases each other,moxibustion group was treated with mild moxibustion ,oryzanol group was treated with oryzanol. The changes of Kupperman,HAMA,E2,FSH,LH,ACTH,CORT were compared before and after treatment between the2 groups. Results: After moxibustion treatment,E2 increased,Kupperman,HAMA and constitution transformation scores , FSH, ACTH and CORT levels were lower than before, compared with oryzanol group, the difference was significant. The decrease of Kupperman score was positively correlated with FSH, CORT and ACTH levels; the improvement of yin deficiency was negatively correlated with the increase of E2,while positively with the descent of CORT and ACTH. Conclusion: Mild moxibustion could reduce the level of FSH,increase the content of E2,the mechanism may relate to the adjustment of the hypothalamic-pituitary-adrenal axis and the hypothalamus-pituitary-gonadal axis , ACTH and CORT are sensitive hormone index in menopausal syndrome with yin deficiency constitution.
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Title Of The Study: Effects of Different Dosage Forms of Oryzanol on Efficacy,sex Hormones Levels and Quality of Life In Patients with Climacteric Syndrome: a Comparative Study
Objective To compare the effects of oryzanol injection and tablets on the efficacy,sex hormones levels and quality of life in patients with climacteric syndrome.Methods A total of 114 patients with climacteric syndrome were selected and were divided into observation group(n=57) and control group(n=57) using random number table.The control group and the observation group were given oryzanol tablets and injection respectively.The efficacy,sex hormones levels,quality of life,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the serum estradiol(E2) level increased significantly but the levels of follicle-stimulating hormone(FSH) and luteinizing hormone(LH) decreased in the two groups compared to the pre-treatment,and the observation group had higher level of E2 and lower levels of FSH and LH compared to the control group(all P<0.05).After treatment,the scores of all dimensions of Menopause-Specific Quality of Life(MENQOL) questionnaire decreased significantly in the two groups compared to the pre-treatment,and the vasomotor and physiological scores in the observation group were lower than those in the control group (P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Oryzanol injection has a definite efficacy on climacteric syndrome.It,which is of good safety,obtains better effects on patients′ sex hormones levels and quality of life compared to oryzanol tablets.
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Title Of The Study: Influence Of Low-dose Sex Hormone Combined with Oryzanol on Sex Hormone of Early Menopause Women
Objective: To observe the effect of clinical application of low-dose sex hormone combined with oryzanol injection on sex hormones in early menopausal women. Methods: Selected 114 patients with early menopause who were diagnosed and treated in our hospital from July 2013 to May 2015, and used a random number table The patients were randomly divided into the control group and the observation group, 57 cases in each. The control group was treated with estradiol and medroxyprogesterone, and the observation group was additionally treated with oryzanol injection. The changes of sex hormones in the two groups before and after treatment were observed. Results: Treatment After treatment, the effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). The E2 level of the two groups increased, and the difference was statistically significant (P<0.05). The difference was statistically significant (P<0.05), and the indexes of the observation group were improved compared with the control group, and the difference was statistically significant (P<0.05). Conclusion: The clinical application of low-dose sex hormone combined with oryzanol injection can significantly Regulating the level of sex hormones in early menopausal women and improving their clinical symptoms can be popularized and applied.
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Title Of The Study: Suanzaoren Decoction(酸枣仁汤) Combined With Flupentixol And Melitracen Tablets And Oryzanol In The Treatment Of Perimenopausal Depression Randomized Controlled Study
[Objective] To observe the Suanzaoren Decoction Combined with Flupentixol and melitracen tablets and oryzanol in the treatment of perimenopausal depression effect. [Methods] 60 outpatients were randomly divided into two groups according to the method of random parallel control. The control group of 30 cases of Flupentixol and melitracen tablets, 0.5 mg/times, 2 times/d, oral; oryzanol, 10 mg/times, 3 times/d, oral. Treatment group, 30 cases of Suanzaoren Decoction(Suanzaoren 30 g, Szechuan lovage rhizome, Poria, Anemarrhena 12 g, licorice 6 g; liver depression of the fire add gardenia, cortex moutan; phlegm heat disturbance and Rhizoma Coptidis, Trichosanthes, gardenia; Yin deficiency and fire wangka dry lotus seed, Ligustrum lucidum, Lily and Rehmannia glutinosa; due to deficiency of Qi and blood, blood Yangxin sunburn and licorice), daily 1 agent, water to cook 400 ml, 2 times daily; western medicine in the treatment of with the control group. Continuous treatment for 1 courses of 15 d. Observation of clinical symptoms, HAMD score, adverse reaction. Treatment of 1 courses of treatment(15 d), determine the efficacy. [Results] The treatment group, 8 cases recovered, 10 cases were markedly effective, 11 cases were effective, 1 case ineffective, effective rate is 96.67%; control group, 4 cases were cured, 8 cases were markedly effective, 9 cases were effective, 9 cases ineffective, efficient 70.00%. The treatment group curative effect surpasses the control group(P<0.05). HAMD score of two groups were improved(P<0.01), the treatment group improved better than the control group(P<0.01). [Conclusion] Suanzaoren Decoction Combined with droperidol thiadiazole tons and deanxit and oryzanol treatment of perimenopausal depressive disorder, and the results were satisfactory. No serious adverse reactions, worthy of promotion.
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Title Of The Study: The Heart can be Curative Effect Observation of Xinkeshu Tablet Combined with Shensongyangxin Capsule in the Treatment of Climacteric Cardiovascular Symptoms
Objective To observe the therapeutic effect of Xinkeshu tablets combined with Shensongyangxin capsule in the treatment of climacteric cardiovascular symptoms. Method 120 cases with cardiovascular symptoms of menopause women were randomly divided into two groups,control group was given conventional Danshen Pill,every time 10 pill,3 times a day,and Oryzanol Tablets 20 mg orally,3 times a day. The treatment group were treated with Xinkeshu tablet,4 tablets each time,3 times a day orally,Shensongyangxin capsule,4 capsules each time,3 times a day orally,two groups were treated for one month. Results The effective rate of the treatment group was 95%,the control group was 85%,there was significant difference between two groups( P < 0. 05),the two groups were no obvious adverse reactions. Conclusion Xinkeshu tablet combined with Shensong Yangxin Capsule in the treatment of menopausal symptoms of cardiovascular effect is effective and safe without side effects.
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Title Of The Study: Curative Efficacy of Oryzanol Combine with dingkundan in Treatment of Perimenopausal Period and its Effects on Endocrine Improvement
Objective To study Curative efficacy of Oryzanol combine with Dingkundan in treatment of perimenopausal period and its effects on endocrine improvement. Methods 90 patients of perimenopausal period who received therapy from March 2014 to March 2015 in our hospital were selected as research objects. According to draw method divided into the experimental group(n=45)and the control group(n=45). Two groups of patient were psychological support. The control group was treated with Oryzanol, each 10 mg, 3 times a day. while the experimental group was on the control group, treated with Dingkundan, 1 pills each time, 2 times a day, in the morning and evening. Then Serum estradiol(E2), Follicle stimulating hormone(FSH), Luteinizinghormone(H)level, upset hot sweating, insomnia, irritability, hung up improve time, Kuppermanscore, clinical efficacy of two groups were compared. Results The E2 level in experimental group was significantly higher than the control group{(72.51‡5.30)pg/mLvs.(66.80‡4.75)pg/mL](P<0.05),FSH, LH level was significantly lower than the control group|(21.36+1.05)mlU/mlvs.(26.09‡1.89)mIU/mL,(24.34‡1.01)mIU/mLvs.(20.61‡1.50)m|U/mL](P<0.05);up se that sweating ,insomnia, irritability, hung up improve time was significantly lower than the control group((11.21‡2.35)d vs.(20.05+5.07)d,(12.78+2.09)d vs.(18.32‡4.13)d, (11.30‡2.10)d vs, (20.16‡55.20)d, (10.20‡2.76)d vs.(16.58‡ 4.03)d](P<0.05);Kupperman score significantly lower than the control group[(4.32 1.09)score vb.(12.76 3.16)score](P<0.05);total effective rate was significantly higher than the control group[93.33%(42/45)vs.75.67%(34/45) (P<0.05).Conclusion Oryzanol combine with Dingkundan is well for perimenopausal period, which can significantly improve endocrine disorders, promote its balance, improve estrogen.
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Title Of The Study: Effect of Adjunctive Treatment with Oryzanol on Menopausal Syndrome and Its Effects on Sex Hormones
Objective To investigate the effect of oryzanol in adjuvant treatment of menopausal syndrome and its effect on the level of sex hormones in patients. Methods A total of 94 patients with menopausal syndrome who were treated in Fushun Central Hospital from May 2017 to May2020 were selected and randomly divided into observation group and There were 47 cases in the control group. The control group was treated with estradiol vale rate, and the observation group was treated with oryzanol on the basis of the treatment in the control group. The levels of sex hormones and menopause quality of life before and after 3 months of treatment were compared between the two groups, as well as the changes in the treatment period. The occurrence of adverse reactions. Results After 3 months of treatment, the serum estradiol level of the observation group was higher than that of the control group, and the levels of luteinizing hormone follicle-stimulating hormone and testosterone were lower than those of the control group, and the differences were statistically significant (all P<0.05). The scores of menopausal quality of life in the observation group were lower than those in the control group, and the differences were statistically significant (all P<0.05). Conclusion: Oryzanol adjuvant therapy for menopausal syndrome can effectively improve the quality of life of patients and improve the level of sex hormones.
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Title Of The Study: Observation on The Efficacy of Oryzanol Combined with Dingkundan in the Treatment of Perimenopause and its Endocrine Improvement
Objective To investigate the curative effect of oryzanol combined with Dingkundan in the treatment of perimenopausal period and its effect on endocrine improvement. Methods 80perimenopausal patients admitted to our hospital from February 2018 to February 2019 were selected. The patients were divided into the study group and the control group, 40 cases in each, the control group was treated with oryzanol, the study group was treated with oryzanol combined with Dingkundan, the clinical efficacy of the two groups of patients was compared and analyzed, and the estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and scores of irritability and sweating, insomnia, emotional irritability, and restlessness improvement time. Results After treatment, the E2 level of the study group was (72.71+3.82) pmol L was significantly higher than the control group (66.68+3.76) pmol/L, FSH (21.56‡1.09) U/L and LH levels(20,64‡1.07) U/L were significantly lower than the control group (26.3011.78) U/L, (24.73‡1.09) U/L; the improvement time of irritable heat, sweating, insomnia, emotional irritability and restlessness in the study group was less than that in the control group, the difference was statistically significant (P<0.05); the clinical effective rate in the study group was 95.00%Compared with the control group, the clinical effective rate was 72.50%, and the difference was statistically significant (P<0.05). Conclusion: Oryzanol combined with Dingkundan has a significant clinical effect in the treatment of perimenopausal women, significantly improves endocrine disorders, and increases the levels of E2, FSH and LH. It is worthy of popularization and application in clinical practice.
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Title Of The Study: Effects of Progesterone Combined with Progesterone and Oryzanol Tablets on Hormone Levels and Bone Mineral Density in Patients with Perimenopausal Syndrome
Objective To investigate the application value of estradiol valerate tablets combined with progesterone and oryzanol tablets in the treatment of patients with perimenopausal syndrome. Methods 48 patients with perimenopausal syndrome who were admitted to our hospital from August 2017 to February 2018 were selected. As the subject of the study. Based on the differences in treatment methods, they were divided into an observation group (n=24) and a control group (n=24). Oryzanol tablets were applied to the control group, and the observation group was based on the control group and premised, adding Using estradiol valerate tablets and progesterone. Comparative analysis of the value of the two treatment methods. Results Before treatment, there was no significant difference in the levels of FSH, LH and E2 between the two groups; after treatment, the observation group compared with the control group, the level of FSH, LH and E2 were significantly improved, and the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in the bone mineral density between the two groups. Compared with the control group, the BMD level of the observation group was significantly improved, and the difference was statistically significant (P<0.05).Conclusion Estradiol valerate tablets combined with progesterone and oryzanol tablets can replace the single use of oryzanol tablets in conventional treatment. In the treatment of patients with perimenopausal syndrome, it is of great significance to improve the patient’s hormone levels and promote the increase of their bone mineral density. Therefore, the clinical application value is significant.
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Title Of The Study: Improvement Effect of Oryzanolum on Endocrine Disorder
of Perimenopausal Women
Objective To research the improvement effect of oryzanolum on endocrine disorder of perimenopausal women. Methods A total of 120 perimenopausal women were selected from the hospital from October 2014 to October 2015.then they were randomly divided into observation group and control group, 60 perimenopausal women in each group. The perimenopausal women in control group were given routine treatment, and the perimenopausal women in observation group were given oryzanol treatment. The levels of estradiol( E2), follicle- stimulating hormone( FSH), luteinizing hormone ( LH), total cholesterol, triglyceride, high- density lipoprotein cholesterol, low- density lipoprotein cholesterol and curative effects after treatment in the two groups were observed. Results After treatment, E2 level in observation group was(68. 25 ‡ 8. 01)pmol / L, which was higher than that in control group [(52. 09 ‡ 7. 23) pmol/ L]; FSH and LH levels in observation group were(34. 12 ‡ 5. 69) U / L and(38. 03 ‡ 10. 01) U / L, respectively, which were statistically significantly lower than those in control group|(46. 10 ‡7. 02) Ü/L and(45. 83 ‡ 11. 05)U/L)(P <0. 05); the levels of total cholesterol and triglyceride in observation group were (7. 56 ‡123) mol/L and(3. 02 ‡ 1. 01) mmol/L ,respectively, which were statistically significantly lower than those in control group{(8. 97 ‡2. 13) mmol/L and(5. 97 ‡1. 28) mmol/LI(P <0. 05); the levels of high- density lipoprotein cholesterol and low- density lipoprotein cholesterol in observation group improvement time of upset hot sweating, insomnia, irritability, and pother in observation group were(12. 09 ‡ 3. 01) days, (14. 01 ‡ 2. 10) days, (10. 20 ‡ 2. 13) days, and(13. 09 ‡2. 72)days, respectively, which were statistically significantly shorter than that in control group [(21. 03‡6. 23) days, (19. 52 ‡5. 10) days, (19. 70 ‡ 6. 10) days, (20. 17 ‡ 6. 08) days](P <0. 05); the total effective rate in observation group was 95. 00%(57 /60), which was statistically significantly higher than that in control group(68. 33%,41 /60)( P < 0. 05). Conclusion The curative effect of oryzanol in treatment of endocrine disorder of perimenopausal women is significant, and the levels ofE2FSH,and LH in these women return to normal.
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