Clinical Trials on
Gamma Oryzanol & formulations with Gamma Oryzanol as the active ingredient on treating cardiovascular diseases
Title Of The Study: Examination of serum lipid, apoprotein, lipoprotein particle size by administration of Probucol, y-Oryzanol
Single dosage of probucol and combined dosage of probucol and y-oryzanol were administered to thirteen patients with hypercholesterolemia to study their effects on serum lipid, apoprotein and lipoprotein particle size. In comparison to the single dosage of probucol, a combined dosage with y-oryzanol. The combined dosage was believed to be effective in preventing at hero sclerosis. Formation of large HDL particles was observed in patients with coronary heart disease (CHD). Probucol administration was conversely found to produce the formation of small HDL particles, Although the low HDL-C state was observed in probucol administration as well as in patients with CHD Probucol administration seems to have a favorable effect on preventing atherosclerosis in terms of HDL particle size in spite of inducing a decrease in HDL-C level.
Title Of The Study: Effects of oral administration of y-oryzanol on HDL-cholesterol
42 diabetic patient with hyperlipidemia were treated with y-oryzanol of 300mg/day for 16 weeks, and the changes of serum lipid levels was followed. Significant reduction of cholesterol, triglyceride, malondialdehyde and atherogenic index was appeared following medication as 270 to 238 mg/d1 (p was less than 0.01),250 to 173mg/dl (p was less than 0.05), 3.6 to 2.1n mol/m/ (p was less than 0,01) and5.0 to 3.4 (p was less than 0.001), respectively. The HDL-cholesterol increased significantly from 47 to 56mg/d’ (p was less than0.001) in both hypo and hyper HDL-cholesterol emic group.
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Title Of The Study: Effect of y-Oryzanol on serum lipids
The effects of y-oryzanol on serum lipids were investigated by the drug to 20 patients with essential hypercholesterolemia at a dosage of 300 mg / day for a period of 16weeks, and observing the change in serum lipids significantly from a pre-treatment value of 253 0mg / d / to 244.5mg / d / after 8weeks (p <0.05) and 228.8mg / d l after 16 weeks (p 0.01) of administration.2. HDL-cholesterol increased from a pretreatment value of 53.8mg / d I to 56.8mg /d I after 8 weeks and 56.2mg / d / after 16 weeks of administration, but these changes were not significant.3. The atherogenic index decreased significantly from a pretreatment value of 4.00 to3.63 after 8 weeks (p <0,01) and 3.48 after 16 weeks (p <0.01) of administration.4. Triglyceride did not change significantly.5. Lipid peroxide decreased significantly from a pre-treatment value of 5.2 mol / mlto 4.2 mol / m ( after 8 weeks (p <0.05) and 3.7 mol / m l after 16 weeks (p <0.05)of administration.6. No drug-related These results suggest that y- oryzanol can be expected to be useful in the treatment of atherosclerosis associated with hypercholesterolemia.
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Title Of The Study: Antilipidemic effect of y-Oryzanol
300mg of y-oryzanol per day was administered to 17 hyperlipemic patients with or without diabetes daily for 16 weeks. Serum lipids (cholesterol, triglyceride, phospholipid, HDL-cholesterol, cholesterylester, B-lipoprotein, lipid peroxide) were analyzed every 4 weeks. Both serum cholesterol and -lipoprotein were decreased in8 or 16 weeks. HDL-cholesterol was slightly increased, but lipid peroxide level was unchanged. Serum triglyceride level was very variable. There was no side effect but one bothered with skin eruption.
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Title Of The Study: About the addition of y-oryzanol to HDL-cholesterol
Effect of the oral administration of y-oryzanol on the levels of plant sterols in whole serum and HDL fraction was studied in I2 patients with hypercholesterolemia and it was examined whether the sterol fraction of y-oryzanol is incorporated into HDL-cholesterol. The sterol fraction of y-oryzanol consisted of 21% camp sterol, 11% ß-sitosterol and68% five other sterols. The plant sterols were found to react with the enzyme system for the determination of cholesterol, that is, campesterol and B-sitosterol It was therefore suggested that the free sterol. It was therefore suggested that the free sterolfraction, which was considered to be the main form of y-oryzanol in blood, may affect the determination of serum or HDL-cholesterol.After the treatment with y-oryzanol 300mg / day for 10 weeks, the concentrations ofcampesterol and f-sitosterol were increased by 43 ug / d / and 15 ug / d /The sum ofthe increases of campesterol and p-sitosterol in the HDL fraction corresponded to 2%of the increase of HDL-cholesterol (28 mg) in the HDL fraction, and 196 ugd L and 85 ug / d / in whole serum, respectively. / d /) and that in whole serumcorresponded to 6% of the increase of total cholesterol (4.6mg / dA).These results indicated that the levels of plant sterols in the HDL fraction or wholeserum must be taken into consideration in order to evaluate accurately the effect of y-oryzanol on HDL-or total cholesterol.
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Title Of The Study: Clinical Curative Effect Of All Kinds Of Arrhythmia Treated With The Combination Of Berberine Hydrochloride,oryzanol And Coenzyme Q10
Objective To observe the clinical efficacy of berberine, oryzanol and coenzyme Q10 in the treatment of various types of arrhythmias. Methods The combination of berberine, oryzanol and coenzyme Q10. Results The total effective rate in the treatment of arrhythmia was 90%. Conclusion The combination is safe, simple and has no side effects. It is one of the effective ways to treat arrhythmia.
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Title Of The Study: Curative Effect of High-dose Oryzanol Combined with Beta-blocker in Treatment Of Cardiovascular Neurosis
Objective To research and explore curative effect of high-dose oryzanol combined with β-blocker in treatment of cardiovascular neurosis.Methods 112 patient with cardiovascular neurosis who were treated in our hospital were given grouping controlled study according to different treatment methods. Patients in the observation group were treated by high-dose oryzanol combined with β-blocker while patients in the observation group were given routine treatment. After continued treatment for 2 weeks, patients were given follow-up and specific curative effects were researched. Results Hamilton Depression Scale (HAMD ), Hamilton Anxiety Rating Scale (HAMA) and score of cardiovascular neurosis of every week in the observation group and the control group were significantly decreased compared with those before treatment.Differences in HAMD score and HAMA score after treatment of every week had statistical significance (P < 0.05). Conclusion High-dose oryzanol combined with β-blocker in treatment of patients with cardiovascular neurosis has good and acute curative effect, which is worthy of widely clinical promotion.
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Title Of The Study: Effect of Large Dose of Oryzanol Combined With Betaloc in the Treatment of Cardiovascular Neurosis
Objective: To explore the effect of large dose of oryzanol combined with betaloc in the treatment of cardiovascular neurosis.Methods:40 patients with cardiovascular neurosis were selected.They were randomly divided into the control group and the observation group.The control group was treated with small dose of oryzanol.The observation group was treated with large dose of oryzanol combined with betaloc.We compared the therapeutic effect of two groups.Results:The total effective rate of the observation group was 95%,which was significantly higher than 75.0% of the control group(P<0.05).Conclusion:The effect of large dose of oryzanol combined with betaloc in the treatment of cardiovascular neurosis was significant.
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Title Of The Study: Efficacy of Cardiovascular Neuroses Treated with High-dose Oryzanol Combined Β-blockers
Objective: To evaluate high-dose oryzanol combined with β-blockers treatment of cardiovascular neurosis patients.Methods: 74 patients with cardiovascular neurosis in our hospital treated with different methods,observation group treated with high dose oryzanol combined β-blockers,control group with conventional treatment,patients were followed up after two weeks.Results: The observation group and control group weekly HAMD score,HAMA scores and cardiovascular neurosis than before treatment were significantly lower.Two weeks after the treatment of the HAMD score and HAMA were significantly different,(t1=2.343,2.252;t2=2.317,2.306;t4=2.298,2.318;t6=2.250,2.431,P<0.05).The observation group 1,2,4,6 weeks after treatment, reduction rate was 53.63%,66.44%,79.58% and 83.74%.The control group 1,2,4 weeks after treatment no significant changes in reduction rate,the difference of two groups were significantly(χ2>3.834).Conclusion: High-dose oryzanol combined β-blockers treatment of cardiovascular neurosis is effective,and it is worthy of clinical application.
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Title Of The Study: High Doses Of Oryzanol In Combination With Betablockers Efficacy In The Treatment Of Cardiovascular Neurosis
Objective To analyze the clinical effect of high-dose oryzanol combined with -blockers on cardiovascular neurosis. Methods Eighty-six patients with cardiovascular neurosis were randomly divided into control group and experimental group, 43 cases in each group. Doses of oryzanol, beta-blockers and high-dose oryzanol were used to treat the two groups of patients, and then the efficacy of the two groups of patients was compared and analyzed. Results The efficacy of the experimental group was significantly better than that of the control group (P<0.05). Conclusions using -blocker combined with high-dose oryzanol in the treatment of patients with cardiovascular neurosis can achieve good therapeutic effect, and this method can be popularized and applied in clinic.
Title Of The Study: The Effects of Quetiapine Combined with Oryzanol on Clinical Symptoms, Blood Glucose and Lipid Metabolism
in Elderly Schizophrenic Patients
Objective To investigate the effects of quetiapine combined with oryzanol on clinical symptoms and blood glucose and lipid metabolism in elderly schizophrenic patients. Methods 120elderly schizophrenic patients treated in our hospital from December 2013 to December 2015were randomly divided into experimental group and control group,60 cases in each group. The experimental group received quetiapine combined with oryzanol treatment. The control group we retreated with quetiapine. The efficacy was evaluated by using the clinical impression scale(CGI), positive and negative symptom scale (PANSS) and treatment emergent symptom scale(TESS),.fasting blood glucose (FBG),total triglyceride (TG), total cholesterol (TC) ,high density lipoprotein (HDL) and low density lipoprotein (LDL).The effects of drugs on the metabolism of glucose and lipid were observed. Results After the treatment, the PANS scores and CGI scores of the two groups were significantly decreased (P<0.05). The CGI scores of the patients in the experimental group were lower than those in the control group at the same time point after the treatment (P<0.05).There was no significant difference between the two groups of patients after one course of treatment and four courses of treatment (P>0.05). The adverse reactions of the treatment group were significantly lower than those of the control group after two courses of treatment and three courses of treatment (P<0.05).There were no significant differences in TG, TC, FBG, HDL and LDL between the two groups before and after treatment (P>0.05).After four courses of treatment, the average fasting blood glucose level was significantly increased in the two groups (P<0.05). Conclusion The results of this study show that the application of quetiapine and oryzanol can effectively improve symptoms, and improve drug safety. The effect on basal metabolism is relatively small.
Title Of The Study: Efficacy of High-dose Oryzanol Combined with Beta-blocker in The Treatment of Cardiovascular Neurosis
Objective: To study the effect of high-dose oryzanol combined with -blockers in the treatment of cardiovascular neurosis. Methods: 80 patients with cardiovascular neurosis who were hospitalized in Nanyang Central Hospital from January 2018 to January 2019 were selected as Research objects, classified according to treatment methods: 40 cases in the control group were treated with low-dose oryzanol, and 40 cases in the observation group were treated with high-dose oryzanol + -blocker. Effect. Results: After treatment, the Hamilton Depression Scale (HAMD),Hamilton Anxiety Scale (HAMA) and symptom scores of the observation group were significantly lower than those of the control group (P<0.05); the total effective rate of treatment was significantly higher than that of the observation group compared with the control group[95.00% VS 67.50%] (P<0.05). Conclusion: The combined treatment of high – dose oryzanol and β blockers in patients with cardiovascular neurosis has a significant effect, which can improve the patients’ negative emotions and relieve heart disease. Symptoms of angioneurosis, the treatment effect is improved.
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Title Of The Study: Effects of Quetiapine and Oryzanol on Clinical Efficacy and Glucose and Lipid Metabolism Insenile Schizophrenia
Objective To explore the effect of quetiapine combined with oryzanol on the clinical efficacy and glucose and lipid metabolism of elderly patients with schizophrenia. Methods 97 elderly patients with schizophrenia who were treated in our hospital from September 2016 to July 2019 were selected as the research objects and randomized The patients were divided into experimental group (n=49) and control group (n=48). The experimental group was treated with quetiapine combined with oryzanol, and the control group was treated with quetiapine alone. The clinical the rapeutic effect and the glucose and lipid metabolism levels of the two groups were observed. Results Before treatment, there was no significant difference in the scores of Clinical Global Impression Scale (CGI) and Positive and Negative Syndrome Scale (PANSS) between the two groups; after treatment, the CGI and PANSS scores of the experimental group were significantly lower than those of the control group (P< 0.05). There was no significant difference in total cholesterol, total triglyceride, high-density lipoprotein, and low-density lipoprotein between the two groups before and after treatment. After treatment, the fasting blood glucose concentrations of the two groups were significantly higher than those before treatment (P<0.05). Before and after treatment, there was no significant difference in total cholesterol, total triglyceride, high density lipoprotein and low density lipoprotein between the two groups. Conclusion: Quetiapine combined with oryzanol in the treatment of elderly patients with schizophrenia can significantly improve the It can improve the curative effect of treatment, and has no significant impact on glucose and lipid metabolism, can effectively reduce the occurrence of metabolic disorders, and has high drug safety, which is worthy of popularization and application.
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Title Of The Study: The Clinical Effect of Atorvastatin Combined with Oryzanol in the Treatment of Coronary Heart Disease Complicated with Arrhythmia for Elderly patients
Objective To investigate the clinical effect of atorvastatin combined with oryzanol in the treatment of elderly patients with coronary heart disease complicated with arrhythmia. Methods104 elderly patients with coronary heart disease complicated with arrhythmia treated in our hospital from December 2015 to September 2017 were selected as the research objects. The patients were divided into the control group and the observation group by random number table method, with 52 cases in each group. Both groups were given the basic treatment of coronary heart disease, the control group was additionally given atorvastatin, the observation group was combined with oryzanol on the basis of the control group, and the treatment of the two groups was observed. The results showed that the total effective rate of the observation group was 96.15%,which was significantly higher than that of the control group, which was 82.69%, and the difference was statistically significant (P<0.05). There was no significant difference in blood lipids and heart rate variability between the two groups (P>0.05). After treatment, TG and TC in the observation group were significantly lower than those in the control group, while SDANN and SDNN were significantly higher than those in the control group, and the difference was statistically significant (P>0.05). P<0.05); the incidence of adverse reactions in the observation group was11.54%, compared with 7.69% in the control group, and the difference was not statistically significant (P>0.05). Conclusion Elderly patients with coronary heart disease complicated with arrhythmia were treated with atorvastatin combined with oryzanol. It has significant effect, can effectively reduce blood lipids, improve heart rate variability, and has high safety, which is worthy of promotion.
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Title Of The Study: Effects of Pitavastatin Calcium combined with Oryzanol on Blood Lipid Levels in the Treatment of 32 Cases of Patients with Hypercholesterolemia
To investigate the effect of pitava statin calcium combined with oryzanol on blood lipid levels in patients with hypercholesterolemia. Methods: A total of 64 patients with primary hypercholesterolemia were selected and randomly divided into control group and study group, 32cases in each group. Vastatin calcium treatment, the study group was given pitavastatin calcium combined with oryzanol treatment. Before and after treatment, blood lipid indexes of the two groups of patients were detected, the clinical efficacy of the two groups of patients was evaluated, and the occurrence of adverse reactions in the two groups of patients during the treatment was observed. Results: Two After treatment, the levels of TG, TC and LDL-C in the patients in the study group were significantly decreased, and the level of HDL-C was significantly increased; the levels of TG, TC and LDL-C in the study group after treatment were significantly lower than tho sein the control group (P<0.05); The level of HDL-C in the study group after treatment was significantly higher than that in the control group (P<0.05). The total effective rate of the treatment in the study group was significantly higher than that in the control group (P<0.05). The incidence of adverse reactions in the two groups was not compared. Significant statistical difference Conclusion: Pitavastatin calcium combined with oryzanol can effectively improve the blood lipid level in patients with hypercholesterolemia, and there are few adverse reactions
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Title Of The Study: The Combination of Amount Oryzanol with Potasium Magnesium As- Partate in the Treatment of Arrhythmias
Objective To investigate the efficacy of high-dose oryzanol combined with potassium and magnesium aspartate in the treatment of arrhythmia. Methods Ninety-seven patients with arrhythmia without atrioventricular block were randomly divided into two groups, the control group of 46 cases, only oral acetaminophen Vetone, 200 mg/time, 3 times/d; 51 cases in the treatment group, on the basis of the medication in the control group, intravenous infusion of potassium and magnesium aspartate injection 200 mL, 1 time/d; oral oryzanol, 100 mg/time, 3 times The course of treatment in both groups was 10 d. Before and after treatment, 12-lead ECG was recorded and blood pressure and blood lipids were detected. During the treatment, ECG was recorded every two days. Results the total efficiency of the treatment group was 90.2%, while that of the control group was61%, the difference between the two was significant (P<0.01). The serum cholesterol in the treatment group decreased significantly before and after treatment (P<0.01). Conclusion Oryzanol and potassium and magnesium aspartate have better effects on the heart. It has a wide range of effects, and the combination of western medicine has a therapeutic effect on arrhythmia from different links, which has a better curative effect, is safe, convenient, inexpensive, easily accepted by patients, and has no obvious adverse reactions. It is a better method for the treatment of arrhythmia.
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Title Of The Study: Clinical observe of effect of Regulating Hyperlipidemia and Weight Reduction by Berberine and Oryzanol
Objective: To study the effect of berberine hydrochloride (Ber) and oryzanol on blood lipid and body weight in patients with dyslipidemia. Methods: Divided 109 patients with cardiovascular disease with dyslipidemia into a treatment group (68 cases) and a control group (41 cases) The treatment group was treated with Ber and oryzanol, and the control group was treated with simvastatin; plasma TC, TG, LDL-C, HDL-C, blood glucose (BG), apolipoprotein B (apo-B) measured before and after treatment in both groups ), liver and kidney function and body weight. Result: The plasma concentration of TC,TG, LDL-C, BG and apo-B in the treatment group were significantly increased by (6.25‡0.19), (3.24‡0.25), (3.78*0.13), (7.56+0.6) mmol/Land(1.01+0.09) g/L decreased to (4.51+0.09), (1.80‡0.12), (2.82+0.10), (6.16+0.29) mmol/Land(0.77+0.23) g/L, the difference was statistically significant before and after treatment (P<0.01);there was no significant effect on renal function before and after treatment (P>0.05), and 18 cases with abnormal transaminase and other abnormalities were significantly improved to normal. 2There was no significant difference in the curative effect of lowering TC between the two groups(P>0.05), but there was a statistically significant difference in lowering TG (P<0.01). Among the 41cases with BMI ≥ 25 in the treatment group, 34 cases of weight were reduced from those before treatment (P<0.01). 71.75+1.88) kg decreased to (66.63+1.83) kg after treatment (P<0.01).Among them, 20 cases had weight loss 25 kg, and there was no obvious adverse reaction; there was no significant difference in the weight of the control group before and after treatment.(P>0.05). Conclusion: It not only has significant effect on reducing TC, TG, LDL-C, BG, apo-B, but also has a significant effect on obesity treatment. It is an efficient, cheap and safe lipid regulating and weight-loss drug.
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