Gamma Oryzanol & formulations with Gamma Oryzanol on Hypothyroidism

Title Of The Study: Effect of y-Oryzanol on Serum TSH Concentrations in Primary Hypothyroidism

A single oral dose (300mg) of y-oryzanol extracted from rice-bran oil produced a significant reduction on the elevated serum TSH levels in hypothyroid patients. Similarly, chronic treatment with y-oryzanol resulted in decreased serum TSH levels in 6 of 8 patients. In addition, there was no difference in the serum TSH response to TR in hypothyroid patients and normal subjects, These observations suggest that y-oryzanol inhibits serum TSH .levels in patients with primary hypothyroidism, possibly by a direct action at the hypothalamus rather than the pituitary.

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